莫沙必利联合马来酸曲美布汀在RE中疗效分析及对MOT、PGE2的影响

Efficacy analysis of Mosapride combined with trimebutine maleate in re and its effect on MOT and PGE2

目的 分析莫沙必利联合马来酸曲美布汀在反流性食管炎(RE)中疗效及对胃动素(MOT)、前列腺素(PGE2)的影响。方法 将133例于2019年1月~2022年1月在我院接受治疗的RE患者纳入研究,并将其根据治疗方法不同分为莫沙必利组64例、联合治疗组69例,莫沙必利组单一使用莫沙必利口服治疗,联合治疗组在其基础上联合马来酸曲美布汀口服治疗,疗程均为2个月。于疗程结束后观察并对比两组研究对象治疗前、治疗后症状评分,食管动力学指标,炎症因子超敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)水平,MOT、PGE2水平以及治疗效果。结果 联合治疗组症状评分、异常收缩比、炎症因子水平低于莫沙必利组(P<0.05);联合治疗组LESR、LESP、LEPP,MOT、PGE2,治疗总有效率高于莫沙必利组(P<0.05)。结论 莫沙必利联合马来酸曲美布汀在RE治疗中疗效较好,对临床症状具有较好的缓解作用,可提高MOT、PGE2水平,保护食管黏膜,促进胃肠道运动恢复正常。

Objective To analyze the curative effect of mosapride combined with trimebutine maleate in reflux esophagitis(RE) and its influence on motilin(MOT) and prostaglandin(PGE2).Methods From January 2019 to January 2022,a total of 133 patients with reflux esophagitis who were treated in our hospital were included in the study, and were divided into mosapride group(64 cases) and combined treatment group(69 cases) according to different treatment methods.Mosapride group was treated with Mosapride alone, and the combined treatment group was treated with trimebutine maleate on the basis of Mosapride alone.The course of treatment was two months.At the end of the course of treatment, the symptom scores, esophageal motility indicators, levels of inflammatory factors such as high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),interleukin-18(IL-18),MOT,PGE2 levels and treatment effects of the two groups of subjects before and after treatment were observed and compared.Results The symptom score, abnormal systolic ratio and inflammatory factor level in the combined treatment group were lower than those in the mosapride group(P<0.05);The total effective rate of LESR,LESP,LEPP,MOT and PGE2 in the combined treatment group was higher than that in the mosapride group(P<0.05).Conclusion Mosapride combined with trimebutine maleate has a good effect in the treatment of RE,and has a better relief effect on clinical symptoms.It can improve the levels of MOT and PGE2,protect esophageal mucosa, and promote gastrointestinal movement to return to normal.