分子遗传学技术在多结节肺癌诊断中的应用现状

Application of molecular genetics technology in the diagnosis of multiple primary lung cancer

多原发肺癌(MPLC)指患者有两个或以上原发肺结节的肺癌,不同结节组织学类型相似的MPLC极易与肺内转移癌(IM)相互误诊,两种诊断的治疗方案和预后差异化明显,目前对于MPLC仍没有诊断的金标准。基于肿瘤的异质性,分子遗传学检测肿瘤的克隆性起源对MPLC的诊断具有重要的参考价值,分子遗传学技术的不断发展使得分子遗传学检测的覆盖范围有所差异,对MPLC的诊断也有所影响。本文针对不同分子遗传学技术在MPLC诊断中的应用做了综述。

Multiple primary lung cancer(MPLC)refers to lung cancer with two or more primary lung nodules. MPLC with similar histological types of different nodules can easily be misdiagnosed with intrapulmonary metastasis(IM). The treatment options and prognosis of the two diagnoses are significantly different. Based on the heterogeneity of tumors,the molecular genetic detection of the clonal origin of tumors has important reference value for the diagnosis of MPLC. The continuous development of molecular genetic technology has made the coverage of molecular genetic testing vary,which also affects the diagnosis of MPLC.The review introduces the application of different molecular biological technology in the diagnosis of MPLC.