HB-EGF、HDAC3联合LP-PLA2检测对老年冠心病患者PCI治疗预后的评估作用

Effect of HB-EGF,HDAC3 combined with LP-PLA2 detection on the prognosis of PCI treatment in elderly patients with coronary heart disease

目的 分析肝素结合性表皮生长因子(HB-EGF)、组蛋白去乙酰化酶3(HDAC3)联合脂蛋白相关磷脂酶A2(LP-PLA2)检测对老年冠心病患者经皮冠状动脉介入(PCI)治疗预后的评估作用。方法 选取2020年5月至2021年5月期间郑州市第七人民医院接收的92例老年冠心病患者,患者均行PCI治疗,随访12个月,根据治疗后是否发生心血管不良事件(MACE),将患者分为MACE组(n=27)和非MACE组(n=65)。使用Logistic回归分析患者PCI术后发生MACE的危险因素,记录HB-EGF、LP-PLA2、HDAC3对PCI术后发生MACE的预测价值。结果 MACE组与非MACE组的LP-PLA2、HDAC3、HB-EGF水平比较差异具有统计学意义(P<0.05)。多元Logistic回归分析结果显示,血清HB-EGF及LP-PLA2、HDAC3水平是冠心病患者PCI后1年内发生MACE的独立危险因素(P<0.05)。依据ROC曲线可知,HB-EGF、LP-PLA2联合HDAC3检测PCI术后发生MACE的敏感度和特异度分别为0.862和0.769;AUC=0.859(95%CI:0.761~0.926),明显高于HB-EGF、LP-PLA2、HDAC3单独检测(P<0.05)。结论 HB-EGF、HDAC3联合LP-PLA2检测对老年冠心病患者PCI预后的评估作用显著,可作为预测MACE的重要依据。

Objective To analyze the effects of Heparin-binding epidermal growth factor(HBEGF),histone deacetylase(HDAC3)combined with lipoprotein-associated phospholipase A2(LP-PLA2)detection on the prognosis of elderly patients with coronary heart disease after percutaneous coronary intervention(PCI). Methods A total of 92 elderly patients with coronary heart disease received by Zhengzhou Seventh People’s Hospital from May 2020 to May 2021 were selected. All patients underwent PCI treatment and were followed up for 12 months. According to whether adverse cardiovascular events(MACE)occurred after treatment,Patients were divided into MACE group(n=27)and non-MACE group(n=65). Logistic regression was used to analyze the risk factors of MACE after PCI,and the predictive value of HB-EGF,LP-PLA2 and HDAC3 on MACE after PCI was recorded. Results There were statistically significant differences in the levels of LP-PLA2,HDAC3,and HB-EGF between the MACE group and the non-MACE group(P<0.05). Multivariate Logistic regression analysis showed that serum HB-EGF,LP-PLA2 and HDAC3 levels were independent risk factors for MACE in patients with coronary heart disease within 1 year after PCI(P<0.05). According to the ROC curve,the sensitivity and specificity of HB-EGF,LP-PLA2 combined with HDAC3 in detecting MACE after PCI were 0.862 and 0.768,respectively,and AUC=0.859(95%CI:0.761-0.926),which were significantly higher than those of HB-EGF,LP-PLA2 and HDAC3 detection alone(P<0.05). Conclusion The detection of HB-EGF,HDAC3 combined with LP-PLA2 plays a significant role in evaluating the prognosis of PCI in elderly patients with coronary heart disease,and can be used as an important basis for predicting MACE.