血清淀粉样蛋白A在972例EB病毒感染儿童中的临床意义

Clinical application of serum amyloid A in 972 children with Epstein-Barr virus infection

目的 探讨血清淀粉样蛋白A(SAA)对EB病毒(EBV)感染儿童诊断的临床意义。方法 选取2019年1月到12月在泰安市中心医院确诊的972例EBV感染的儿童作为实验组,并同时选择200例随机抽取的健康体检儿童作为对照组,在EBV感染儿童入院后抽取空腹的静脉血,分别检测全血SAA、CRP和EBV-DNA。分析SAA、CRP在EBV感染儿童及健康对照组中的含量变化,以及EBV感染儿童中病毒载量与SAA浓度的变化趋势。结果 EBV感染儿童组的SAA及CRP水平显著高于健康对照组(Z=-16.01、-11.18),差异有统计学意义(P<0.05);EBV感染儿童组的SAA的阳性率(71.7%)明显高于CRP的阳性率(39.8%)(χ^(2)=200.4),差异有统计学意义(P<0.05);EBV低载量组儿童的SAA浓度高于高载量组(Z=-2.46),差异有统计学意义(P<0.05)。结论 在EBV感染诊断中SAA的敏感性要优于CRP,SAA的检测可以作为诊断儿童感染EBV的一个重要的指标。

Objective To explore the clinical value of serum amyloid A(SAA)in the diagnosis of Epstein-Barr virus(EBV)infected children. Methods A total of 972 children with EBV infection diagnosed in Tai’an Central Hospital from January to December 2019 were selected as the experimental group,and 200 randomly selected healthy children were selected as the control group. Fasting venous blood was drawn from EBVinfected children after admission,and whole blood SAA,CRP and EBV-DNA were detected. The content changes of SAA and CRP in EBV-infected children and healthy controls,as well as the trend of viral load and SAA concentration in EBV-infected children were analyzed. Results The levels of SAA and CRP in EBV infected children were significantly higher than those in the healthy controls(Z=-16.01、-11.18),and the difference was statistically significant(P<0.05). The positive rate of SAA in EBV infected children(71.7%)was higher than that of CRP(39.8%)(χ^(2)=200.4),the difference was statistically significant(P<0.05). The SAA concentration of children in the EBV low load group was higher than that in the high load group(Z=-2.46),and the difference was statistically significant(P<0.05). Conclusion The sensitivity of SAA in the diagnosis of EBV infection is better than that of CRP,and the detection of SAA can be used as an important indicator for the diagnosis of EBV infection in children.