低频电刺激对产后压力性尿失禁患者RLX、E2及TGF-β1的影响

Effects of low-frequency electrical stimulation on RLX,E2 and TGF-β1 in patients with postpartum stress urinary incontinence

目的 探讨低频电刺激对产后压力性尿失禁患者松弛素(RLX)、雌二醇(E2)、转化生长因子-β1(TGF-β1)的影响。方法 选取郑州市第七人民医院2020年1月至2022年5月期间收治的122例产后压力性尿失禁女性患者作为研究对象,遵循医嘱采用不同治疗方法进行分组,分为观察组(常规盆底康复治疗+低频电刺激,n=62)、对照组(常规盆底康复治疗,n=60),比较两组患者盆底情况、RLX、E2、TGF-β1、Ⅰ类肌纤维、Ⅱ类肌纤维、子宫脱垂、阴道前后壁膨出与最大尿道闭合压(MUCP)、膀胱顺应性(BC)及漏尿点压力(VLPP)。结果 与治疗前相比,治疗后观察组RLX水平低于对照组,E2水平、TGF-β1水平、MUCP、VLPP、BC指标均高于对照组,两组患者肌力均提升,其中观察组Ⅰ、Ⅱ类肌纤维的肌力均高于对照组,疲劳度低于对照组,且观察组子宫脱垂、阴道前壁膨出、阴道后壁膨出发生率均低于对照组,差异均有统计学意义(P<0.05)。结论 低频电刺激可改善产后压力性尿失禁患者盆底功能,对机体激素及蛋白合成均有一定影响,可进一步研究证实。

Objective To investigate the effects of low-frequency electrical stimulation on relaxin(RLX),estradiol(E2)and transforming growth factor-β1(TGF-β1)in patients with postpartum stress urinary incontinence. Methods 122 female patients with postpartum stress urinary incontinence who were admitted to Zhengzhou Seventh People’s Hospital from January 2020 to May 2022 were selected as the research subjects,and according to the doctor ’ s orders,the patients with different treatment methods were divided into the observation group(conventional pelvic floor rehabilitation therapy + low-frequency electrical stimulation,n=62),and the control group(conventional pelvic floor rehabilitation therapy,n=60),and the pelvic floor,RLX,E2,TGF-β1,type Ⅰ muscle fibers,type Ⅱ muscle fibers,uterine prolapse,vaginal anterior and posterior wall bulge,maximum urethral closure pressure(MUCP),bladder compliance(BC)and leakage were compared between the two groups. Results Compared with before treatment,after treatment,the level of RLX in the observation group was lower than that in the control group,while E2 level,TGF-β1 level,MUCP,VLPP and BC indexes in the observation group were higher than those in the control group,and the muscle strength of the two groups was improved,and the muscle strength of classⅠmuscle fibers and classⅡmuscle fibers in the observation group were higher than those in the control group,and their fatigue was lower than that in the control group,the incidences of uterine prolapse,vaginal anterior wall prolapse and vaginal posterior wall prolapse in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05). Conclusion Low-frequency electrical stimulation can improve pelvic floor function in patients with postpartum stress urinary incontinence,and has certain effects on hormone and protein synthesis in the body,which can be confirmed by further research.