白介素-33对树突状细胞的免疫调控效应及其在疾病中的作用

Immunomodulatory Effect of Interleukin-33 on Dendritic Cells and Its Role in The Pathogenesis of Various Diseases

白介素(interleukin,IL)-33是近年来广泛研究的白介素-1家族细胞因子。既往研究大多集中在IL-33对其经典靶细胞,如肥大细胞、2型固有淋巴细胞的作用。树突状细胞(dendritic cell,DC)是目前所知功能最强的专职抗原呈递细胞。已证实,IL-33可以通过其特异性受体对DC发挥免疫调控作用,进而影响机体免疫功能状态和介导疾病的发生与发展过程。本文就IL-33调控DC的作用及机制做一综述,为进一步探究其免疫效应与调理途径提供新线索。

Interleukin(IL)-33, a nuclear factor and a cytokine of the IL-1 family, has received a lot of attention in recent years because of its important role in chronic inflammatory and autoimmune diseases. It appears to be critically involved in the regulation of various physiological processes by influencing a wide range of immune cells. Previous reports and studies have primarily focused on the effects of IL-33 on traditional target cells, such as mast cells and type 2 innate lymphocytes. Dendritic cells(DC) are the most functionally specialized antigenpresenting cells that have been discovered to date. It has been demonstrated that IL-33 can activate DC via its specific receptor serum stimulation-2(ST2), thereby regulating the host immune response and playing key roles in the pathogenesis of occurrence and progression of various diseases. The immune regulation of DC by IL-33 mainly involves signal pathways, such as NF-κB, p38 MAPK, and STAT1/3, in turn mediating the maturation,differentiation, and inflammatory response of DC. In addition, DC is an important source of the secretion of IL-33, which enhances the immune reaction and Th2 response through a positive feedback amplification loop.IL-33 activated DCs can promote tumor immunity and resist pathogen invasion, and also participate in the development of autoimmune and inflammatory diseases. This paper reviews the potential role and underlying mechanism of IL-33 in regulating DC immune response in order to provide a foundation for further research into its immune function and modulatory pathway in diseases.