基于CiteSpace知识图谱的中药致心脏不良反应研究可视化分析

Visual analysis of ADR induced by Chinese medicine based on CiteSpace knowledge maps

目的围绕中药致心脏不良反应文献进行可视化分析,探讨该领域研究现状及发展趋势。方法分别检索中国知网、万方数据、维普网中文文献数据库1980年1月1日至2022年1月31日的中药致心脏不良反应相关文献,利用CiteSpace5.8.R2软件对发表年份、期刊、作者、机构、关键词进行分析。结果中药致心脏不良反应领域年发文量逐渐升高;对该领域的研究已经形成了稳定的6个核心研究团队,但各团队间合作较少;作者冯群、关月晨等发文量最高,对推动该领域发展有重要指导作用;研究热点方向集中在中药致心脏不良反应机制预测、心脏不良反应中药炮制配伍减毒研究以及心脏毒性评价指标(心电图、心肌细胞、离子通道等)。结论中药致心脏不良反应的研究整体呈上升态势,研究热点主要是有毒中药心脏毒性及中药配伍炮制减毒;突现分析提示:研究中药心脏不良反应的评价指标,建立中药研发评价体系,基于斑马鱼模型探索中药配伍减毒进一步的分子机制以及各种标示物之间是如何协同或拮抗而发挥作用可能是以后重点研究的方向。

Objective To keep track of the current research and developments related to adverse cardiac reactions caused by traditional Chinese medicine through visual analysis.Methods Literature that was published between January 1,1980 and January 31,2022 and concerned with adverse cardiac reactions caused by traditional Chinese medicines was retrieved from CNKI,Wanfang and VIP databases respectively.CiteSpace5.8.R2 software was used to analyze the years of publication,journals,authors,institutions and key words.Results The number of articles published in the field of cardiotoxicity caused by traditional Chinese medicines gradually increased.Six stable core research teams were formed in this field,but there was little collaboration between them.The number of publications by Feng Qun and Guan Yuechen respectively was the largest,which played an important role in promoting the development of this field.Research focused on the mechanism prediction of ADR induced by TCM,the toxicity reduction of TCM processing and compatibility,and the evaluation indexes of cardiotoxicity(electrocardiograms,cardiomyocytes and ion channels).Conclusion There has been more research on adverse cardiac reactions caused by traditional Chinese medicines,especially on the cardiotoxicity of toxic traditional Chinese medicines and the combination of traditional Chinese medicines.Emergent analysis suggests that more effort will be made to study the evaluation indexes of cardiotoxicity of TCM,establish the evaluation system of TCM research and development,elucidate the molecular mechanism of TCM compatibility and toxicity reduction based on zebrafish models,and find out how various markers play a synergistic or antagonistic role.