体外冲击波碎石术联合排石通淋汤与盐酸坦索罗辛缓释胶囊治疗泌尿系结石临床研究

Clinical Study on Extracorporeal Shock Wave Lithotripsy Combined with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained-Release Capsules for Urinary Calculi

目的:观察体外冲击波碎石术(ESWL)联合排石通淋汤与盐酸坦索罗辛缓释胶囊治疗泌尿系结石湿热蕴结证的临床疗效。方法:选择86例泌尿系结石湿热蕴结证患者,采用随机数字表法分为观察组和对照组各43例。2组均给予ESWL治疗,对照组术后服用盐酸坦索罗辛缓释胶囊治疗,观察组术后给予排石通淋汤联合盐酸坦索罗辛缓释胶囊治疗,2组均治疗2周,随访3个月。比较2组临床疗效、症状消失时间、不良反应发生率、复发率。结果:治疗后,观察组治愈率97.67%,高于对照组83.72%,差异有统计学意义(P<0.05)。观察组结石排尽、腰痛消失及肉眼血尿消失时间均短于对照组(P<0.05)。观察组不良反应发生率2.33%,与对照组4.65%比较,差异无统计学意义(P>0.05)。观察组复发率4.76%,低于对照组19.44%,差异有统计学意义(P<0.05)。结论:ESWL联合排石通淋汤与盐酸坦索罗辛缓释胶囊治疗泌尿系结石湿热蕴结证临床效果显著,可有效缩短结石排尽及症状消失时间,降低复发率,提高结石排尽率,安全性好。

Objective:To observe the clinical effect of extracorporeal shock wave lithotripsy(ESWL)combined with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained-Release Capsules for urinary calculi with damp-heat accumulation syndrome.Methods:A total of 86 cases of patients with urinary calculi with damp-heat accumulation syndrome were selected and divided into the observation group and the control group according to the random number table method,with 43 cases in each group.Both groups were treated with ESWL;after operation,the control group was treated with Tamsulosin Hydrochloride Sustained-Release Capsules,and the observation group was treated with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained-Release Capsules.Both groups were treated for2 weeks,and follow up for 3 months.The clinical effects,disappearance time of symptoms,recurrence rates and incidence of adverse reactions were compared between the two groups.Results:After treatment,the cure rate was 97.67% in the observation group,higher than that of 83.72% in the control group,the difference being significant(P<0.05).The stone expulsion time,the disappearance time of low back pain and the disappearance time of gross hematuria in the observation group were shorter than those in the control group(P<0.05).The incidence of adverse reactions was 2.33% in the observation group and4.65% in the control group,there being no significance in the difference(P>0.05).The recurrence rate was4.76% in the observation group,lower than that of 19.44% in the control group,the difference being significant(P<0.05).Conclusion:ESWL combined with Paishi Tonglin Decoction and Tamsulosin Hydrochloride Sustained-Release Capsules for urinary calculi with damp-heat accumulation syndrome,which can effectively shorten the stone expulsion time and the disappearance time of symptoms,reduce the recurrence rates and improve the stone expulsion rates,with good safety.