银花泌炎灵片联合抗生素治疗湿热瘀阻证盆腔炎性疾病后遗症临床研究

Clinical Study on Yinhua Miyanling Tablets Combined with Antibiotics for Sequelae of Pelvic Inflammatory Disease with Damp-Heat Stagnation Syndrome

目的:观察银花泌炎灵片联合抗生素治疗湿热瘀阻证盆腔炎性疾病后遗症(PID)的临床疗效及其对血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平的影响。方法:选取PID患者64例,按随机数字表法分为治疗组和对照组各32例。对照组给予奥硝唑片、左氧氟沙星片等常规抗菌治疗,治疗组在对照组的基础上加用银花泌炎灵片治疗。2组均治疗3个月经周期。比较2组血常规指标、湿热瘀阻证证候评分、IL-6、IL-8水平及总体临床疗效。结果:治疗组总有效率为96.88%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组白细胞计数、中性粒细胞比例比较,差异无统计学意义(P>0.05);治疗后,2组白细胞计数、中性粒细胞比例均较治疗前显著降低(P<0.05),且治疗组2项指标均低于对照组(P<0.05)。治疗前,2组下腹胀痛且痛处固定、腰骶胀痛、带下量多、白带色黄质稠、低热起伏、神疲乏力、月经量多、小便黄赤、大便干燥等中医证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项中医证候评分均较治疗前明显降低(P<0.05),且治疗组各项证候评分均低于对照组(P<0.05)。治疗前,2组血清IL-6、IL-8水平比较,差异无统计学意义(P>0.05);治疗后,2组IL-6、IL-8水平均较治疗前明显降低(P<0.05),且治疗组2项指标均低于对照组(P<0.05)。结论:银花泌炎灵片联合抗生素治疗湿热瘀阻证PID能进一步抑制炎症反应,明显改善中医证候,疗效优于单纯抗生素治疗。

Objective:To observe the clinical effect of Yinhua Miyanling Tablets combined with antibiotics for sequelae of pelvic inflammatory disease(PID)with damp-heat stagnation syndrome and its effect on levels of interleukin-6(IL-6)and interleukin-8(IL-8)in serum.Methods:A total of 64 cases of patients with sequelae of PID were selected and divided into the treatment group and the control group according to the random number table method,with 32 cases in each group.The control group was given routine antimicrobial therapy including Ornidazole Tablets and Levofloxacin Tablets,and the treatment group was additionally treated with Yinhua Miyanling Tablets based on the treatment of the control group.Both groups were treated for 3 menstrual cycles.The blood routine indexes,syndrome scores of dampheat stagnation syndrome,levels of IL-6 and IL-8 in serum,and total clinical effects were compared between the two groups.Results:The total effective rate was 96.88% in the treatment group and 75.00% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of white blood cell counts and neutrophil proportion between the two groups(P>0.05).After treatment,the white blood cell counts and neutrophil proportion in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the two indexes in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of traditional Chinese medicine(TCM)syndromes including distending pain in lower abdominal,fixation in pain place,distending pain in lumbosacral spine,large leukorrhea amount,yellow and thick leukorrhea,alternative low-grade fever,mental fatigue and lack of strength,large menstrual volume,brown urine and dry stool between the two groups(P>0.05).After treatment,the above TCM syndrome scores in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above TCM syndrome scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IL-6 and IL-8 in serum between the two groups(P>0.05).After treatment,the levels of IL-6 and IL-8 in serum in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the two indexes in the treatment group were lower than those in the control group(P<0.05).Conclusion:Yinhua Miyanling Tablets combined with antibiotics for PID with damp-heat stagnation syndrome can further inhibit inflammatory responses and significantly improve TCM syndromes,whose curative effect is better than that of simple antibiotics.