活血化瘀汤保留灌肠联合离子透药疗法治疗气滞血瘀型慢性盆腔炎临床研究

Clinical Study on Retention Enema with Huoxue Huayu Decoction Combined with Herbal Ion Penetration Therapy for Chronic Pelvic Inflammatory Disease of Qi Stagnation and Blood Stasis Type

目的:观察在奥硝唑氯化钠注射液治疗基础上加用活血化瘀汤保留灌肠联合离子透药疗法治疗气滞血瘀型慢性盆腔炎(CPID)的临床疗效。方法:选取88例气滞血瘀型CPID患者,按随机数字表法分成对照组和研究组各44例。对照组给予奥硝唑氯化钠注射液治疗,研究组在对照组基础上给予活血化瘀汤保留灌肠联合离子透药疗法治疗,2组均治疗2周,随访6个月。比较2组临床疗效、中医证候积分、血清C-反应蛋白(CRP)水平及复发率。结果:治疗1周、2周,2组下腹疼痛、腰骶胀痛、月经异常、带下异常积分均较治疗前降低(P<0.05),研究组下腹疼痛、腰骶胀痛、月经异常、带下异常积分均低于同期对照组(P<0.05)。研究组临床疗效总有效率90.91%,高于对照组72.73%(P<0.05)。治疗1周、2周,2组血清CRP水平均较治疗前降低(P<0.05),研究组血清CRP水平均低于同期对照组(P<0.05)。随访6个月,研究组无复发,对照组复发率15.63%,2组比较,差异有统计学意义(P<0.05)。结论:在奥硝唑氯化钠注射液治疗基础上加用活血化瘀汤保留灌肠联合离子透药疗法治疗气滞血瘀型CPID效果显著,有助于缓解临床症状、减轻炎症反应、减少复发。

Objective:To observe the clinical effect of the additional application of retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy for chronic pelvic inflammatory disease(CPID)of qi stagnation and blood stasis type based on the treatment of Ornidazole Sodium Chloride Injection.Methods:A total of 88 cases of CPID patients of qi stagnation and blood stasis type were selected and divided into the control group and the study group according to the random number table method,with 44 cases in each group.The control group was treated with Ornidazole Sodium Chloride Injection,and the study group was additionally treated with retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy based on the treatment of the control group.Both groups were given 2-week treatment and 6-month follow-up.The clinical effects,traditional Chinese medicine syndrome scores,levels of C-reactive protein(CRP)in serum,and the recurrence rates were compared between the two groups.Results:After 1-week and 2-week treatment,the scores of lower abdominal pain,lumbosacral spinal fullness and weakness,abnormal menstruation,and abnormal leukorrhea in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of lower abdominal pain,lumbosacral spinal fullness and weakness,abnormal menstruation,and abnormal leukorrhea in the study group were lower than those in the control group at the same period(P<0.05).The total effective rate of clinical effect was 90.91% in the study group,higher than that of 72.73% in the control group(P<0.05).After 1-week and 2-week treatment,the CRP levels in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the CRP level in serum in the study group was lower than that in the control group at the same period(P<0.05).After 6-month followup,there was no recurrence in the study group,and the recurrence rate was 15.63% in the control group,there being significance in the difference(P<0.05).Conclusion:Based on the treatment of Ornidazole Sodium Chloride Injection,the additional application of retention enema with Huoxue Huayu Decoction combined with herbal ion penetration therapy has a significant effect in treating CPID of qi stagnation and blood stasis type,which is helpful to relieve clinical symptoms,decrease inflammatory responses and reduce recurrence.