人工关节置换术治疗膝关节骨性关节炎的疗效

Efficacy of Total Knee Arthroplasty in Treatment of Knee Osteoarthritis

目的:探讨人工关节置换术治疗膝关节骨性关节炎的疗效。方法:选取2019年9月-2021年12月阳新县中医医院收治的100例膝关节骨性关节炎患者为研究对象,采用随机数字表法分为观察组和对照组,各50例。对照组采用常规手术治疗方式,观察组采用人工关节置换术进行治疗。比较两组治疗前后血清超氧化物歧化酶(SOD)、一氧化氮(NO)、肿瘤坏死因子-α(TNF-α)水平及并发症、膝关节功能情况。结果:治疗前,两组SOD、NO、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,观察组SOD水平高于对照组,NO、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P=0.028)。治疗前,两组关节肌力、屈曲畸形、稳定性、关节活动度、疼痛、功能评分比较,差异无统计学意义(P>0.05);治疗后,观察组关节肌力、屈曲畸形、稳定性、关节活动度、疼痛、功能评分均高于对照组,差异有统计学意义(P<0.05)。结论:膝关节骨性关节炎患者采用人工关节置换术进行治疗,效果显著,治疗后患者的并发症发生情况较少,生活质量较高。

Objective:To explore the efficacy of total knee arthroplasty in treatment of knee osteoarthritis.Methods:A total of 100 patients with knee osteoarthritis who were treated in Yangxin County Hospital of Traditional Chinese Medicine from September 2019 to December 2021 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group adopted routine surgical treatment,and the observation group adopted total knee arthroplasty.Serum superoxide dismutase(SOD),nitric oxide(NO),tumor necrosis factor-α(TNF-α),complications,and knee joint function score(Hospital for Special Surgery,HSS)before and after treatment were compared between the two groups.Results:Before treatment,there was no significant difference in the levels of SOD,NO and TNF-αbetween the two groups(P>0.05).After treatment,the SOD level in the observation group was higher than that in the control group,and the levels of NO and TNF-αin the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.028).Before treatment,there were no significant differences in joint muscle strength,flexion deformity,stability,joint range of motion,pain and function scores between the two groups(P>0.05).After treatment,the joint muscle strength,flexion deformity,stability,joint range of motion,pain and function scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:The total knee arthroplasty in treatment of patients with moderate and severe knee osteoarthritis has a higher efficiency,less complications,and higher quality of life.