噻托溴铵粉联合多索茶碱治疗慢性阻塞性肺疾病的效果

Effect of Tiotropium Bromide Powder Combined with Doxofylline in Treatment of Chronic Obstructive Pulmonary Disease

目的:分析噻托溴铵粉联合多索茶碱治疗慢性阻塞性肺疾病的效果。方法:选取2020年8月-2022年1月北京市房山区良乡医院收治的80例慢性阻塞性肺疾病患者作为研究对象,根据随机数字表法分为观察组和对照组,各40例。两组均采用常规治疗方法,对照组在常规治疗基础上给予多索茶碱治疗,观察组在对照组基础上给予噻托溴铵粉治疗,比较两组治疗效果、肺功能相关指标、不良反应发生情况、生活质量评分。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肺活量(FVC)、第1 s用力呼气容积(FEV_(1))、FEV_(1)与用力肺活量的比值(FEV_(1)/FVC)比较,差异无统计学意义(P>0.05);治疗后,观察组FEV_(1)、FVC、FEV_(1)/FVC均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组慢性阻塞性肺疾病评估测试(CAT)评分比较,差异无统计学意义(P>0.05);治疗后,观察组CAT评分低于对照组,差异有统计学意义(P<0.05)。结论:对慢性阻塞性肺疾病患者采用噻托溴铵粉联合多索茶碱进行治疗,可提高治疗效果,改善患者的肺功能情况,且不良反应发生率较低,安全性较高。

Objective:To analyze the effect of tiotropium bromide powder combined with doxofylline in the treatment of chronic obstructive pulmonary disease.Methods:From August 2020 to January 2022,80 patients with chronic obstructive pulmonary disease admitted to Liangxiang Hospital of Fangshan District of Beijing were selected as the study subjects,and they were divided into observation group and control group according to the random number table method,with 40 cases in each group.Both groups adopted conventional treatment,the control group was treated with doxofylline on the basis of conventional treatment,and the observation group was treated with tiotropium bromide powder on the basis of the control group.The treatment effect,lung function related indicators,adverse reaction occurrence and quality of life scores between the two groups were compared.Results:The total response rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the forced vital capacity(FVC),forced expiratory volume in 1 s(FEV_(1)),and FEV_(1)/FVC ratio between the two groups(P>0.05).After treatment,FEV_(1),FVC,FEV_(1)/FVC in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no significant difference in the the scores of chronic obstructive pulmonary disease assessment test(CAT)between the two groups(P>0.05).After treatment,the CAT score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:The combination of tiotropium bromide powder and doxofylline in patients with chronic obstructive pulmonary disease can enhance treatment effect,and improve the patient’s pulmonary function,with low incidence of adverse effects and high safety.