摘要
Four unreported monoterpene indole alkaloids,tabernaecorymines B−E(1−4),together with twenty-one known indole alkaloids(5−25)were obtained from the stem bark of Tabernaemontana corymbosa.Their structures and absolute configurations were elucidated by extensive spectroscopy,quantum chemical calculations,DP4+probability analyses and Mo2(OAc)4-induced electronic circular dichroism experiment.The antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus,Bacillus subtilis,Streptococcus dysgalactiae and Candida albicans.
基金
supported by the National Natural Science Foundation of China(Nos.31900290 and 32000274)
Yunnan Province Young Academic Project(No.202105AC160078)
the Scholar of Yunling(No.YNWR-YLXZ-2019-019)
the Basic Project in Yunnan Province(No.202101AU070069)
the Development and Application of Biotic Resource in Yunnan Province(No.202002AA100007)
Yunnan Key Laboratory of Pharmacology for Natural Products Fund Project.
