摘要
干细胞是一种未分化的、自我再生的多能细胞,具有分化成任何细胞类型或组织的潜能,在再生医学的细胞治疗中有巨大潜力。其中间充质干细胞具有干细胞所有的共性,并且易于获得,具有稳定的生物学特征,是临床上应用最多的干细胞。间充质干细胞可来源于骨髓、脂肪组织、脐带等。但是,在应用这种细胞治疗的同时,也出现了一系列的挑战如干细胞的移植率低、存活率低等一些问题需要克服。有研究发现干细胞的存活和增殖受到晚期糖基化终末产物与其受体结合后激活的氧化应激、释放的炎症因子所形成的微环境的影响。本文结合相关研究文献,就晚期糖基化终末产物激活的p38蛋白激酶、丝裂原活化蛋白激酶通路对间充质干细胞活力以及增殖的影响及相关机制进行综述。
Stem cells are undifferentiated,self-regenerating,pluripotential cells which have the potential to differentiate into any cell type or tissue.There is great potential for cell therapy in regenerative medicine.Mesenchymal stem cells have all the characteristics of stem cells and are easy to obtain and have stable biological characteristics.It is the most widely used stem cell in clinical practice.Mesenchymal stem cells can be derived from bone marrow,adipose tissue,umbilical cord,etc.However,at the same time there are a number of challenges,lower transplant rate,and lower survival rate.One study has found that the survival and proliferation of stem cells is influenced by microenvironment that advanced glycation end-products combined with the receptor of advanced glycation end-products activating oxidative stress and inflammatory factors.In this article,the effect of advanced glycation end-products on stem cells of survival and proliferation are analyzed.
作者
管璐璐
徐积兄
Guan Lulu;Xu Jixiong(Department of Endocrine and Metabolism,First Affiliated Hospital of Nanchang University,Jiangxi Clinical Research Center for Endocrine and Metabolic Disease,Jiangxi Branch of National Clinical Research Center for Metabolic Disease,Nanchang 330006,China)
出处
《国际内分泌代谢杂志》
2023年第1期50-53,共4页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金(81760618)。
关键词
间充质干细胞
增殖
凋亡
晚期糖基化终末产物
晚期糖基化终末产物受体
Mesenchymal stem cell
Proliferation
Apoptosis
Advanced glycation end-products
Receptor of advanced glycation end-products
