摘要
综述了熔体结晶应用于药物多晶型领域的研究进展,包括常规熔体结晶、聚合物诱导熔体结晶、纳米限域熔体结晶和熔体微液滴培养单晶技术,以期助力药物多晶型和固态化学研究。
Here we reviewed recent advances of melt crystallization in pharmaceutical polymorphism,including routine melt crystallization,polymer-assistant crystallization,nanoconfinement crystallization and melt microdroplet strategy for single-crystal cultivation.This work aims to promote the research in drug polymorphism and solid-state chemistry.
作者
李淑婷
李澳
刘彬彬
陆明
LI Shuting;LI Ao;LIU Binbin;LU Ming(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China)
出处
《化学工业与工程》
CAS
CSCD
北大核心
2023年第1期41-52,共12页
Chemical Industry and Engineering
关键词
熔体结晶
药物多晶型
聚合物诱导结晶
纳米限域结晶
熔体微液滴培养单晶技术
melt crystallization
pharmaceutical polymorphism
polymer-assistant crystallization
nanoconfinement crystallization
melt microdroplet strategy for single-crystal cultivation
