GSDM家族蛋白在细胞焦亡中的作用研究进展

Research progress on the role of GSDM family proteins in pyrodeath of cells

细胞焦亡作为炎性反应性的调控性细胞死亡,在生物体抵御外来病原体及各种临床疾病中发挥着重要作用,近年来焦亡通过Caspase激活的具体机制研究取得了突破性的进展,gasdermin D蛋白(GSDMD)作为Caspase底物被切割并发挥针对细胞膜的穿孔作用,诱导细胞焦亡,其他GSDMs家族蛋白在焦亡中的作用也逐渐被阐明。细胞焦亡已被认为是GSDM家族蛋白介导的程序性死亡过程,其在肿瘤及其他临床疾病中的机制研究显得越来越重要。文章就GSDM家族蛋白在细胞焦亡中的作用研究进展作一综述。

Pyroptosis, as an inflammatory regulatory cell death, plays an important role in the process of organism’s defense against foreign pathogens as well as other disease. The specific mechanism of pyroptosis through Caspase activation has made breakthrough progress in recent years. GSDMD protein, as a Caspase substrate, cleaved and perforated the cell membrane to induce pyroptosis. The role of other GSDMs family proteins in pyroptosis has also been gradually elucidated. Pyroptosis has been recognized as a programmed death process mediated by GSDM family proteins.