肠道微生态与新型冠状病毒感染

Gut microbiota and the coronavirus disease 2019

肠道微生态通过微生物代谢物、微生物相关分子模式以及微生物与免疫细胞之间的相互作用调节远端器官的免疫反应。由SARS-CoV-2引起的新型冠状病毒感染(COVID-19)可通过直接感染肠道或间接免疫对肠道微生态产生影响,肠道微生态也可通过菌群多样性和特定微生物与病毒的相互作用或者其产物对病毒产生影响。肠道菌群中青春型双歧杆菌等有益菌对COVID-19疫苗的抗体产生有促进作用,包括灭活疫苗和RNA疫苗。肠道微生态紊乱对部分COVID-19患者可产生长期影响,调整肠道微生态的干预措施如粪菌移植对COVID-19具有潜在有益的作用。

Gut microbiota regulates the immune response of distal organs through microbiota-metabolites,microbiota related molecular patterns and interactions between microorganisms and immune cells.The gut microbiota can be affected by direct infection of intestine or indirect immunity in coronavirus disease 2019(COVID-19)epidemic caused by SARS-CoV-2.The gut microbiota can also affect the virus through the diversity of microbiota and the interaction of specific microorganisms and viruses or their metabolites.Beneficial bacteria such as Bifidobacterium adolescentis in the gut microbiota can promote the production of antibodies against COVID-19 vaccine,including inactivated vaccine and RNA vaccine.Microbiota disorder has a long-term impacts on some COVID-19 patients,and interventions of gut microbiota,such as fecal microbiota transplantation,having a certain effect on the treatment of COVID-19.