肠道微生态与脓毒症

Intestinal microecology and sepsis

脓毒症是PICU常见的危重症,病死率高,临床十分棘手,但其发病机制并未十分明确。目前认为脓毒症早期,胃肠道是最容易受累的器官之一,肠道微生态在脓毒症的发生、发展及转归中起到了重要作用。其中,肠道菌群失调/移位与脓毒症关系密切,互为影响,最终导致并加剧多器官功能障碍。本文就脓毒症中肠道微生态变化及发病机制、治疗进展等方面作一综述。

Sepsis is a common critical illness in PICU,with high morbidity and mortality.As the pathogenesis is still not well defined,the clinical management of sepsis can be tricky.The gastrointestinal tract is currently considered as one of the most susceptible organs in the early stages of sepsis,and intestinal microecology plays important roles in the development,progression and prognosis of this disease.There is a closely relationship between intestinal flora dysbiosis/translocation and sepsis.They interact with each other,and ultimately leading to multi-organ dysfunction.In this review,we provided a brief summary of intestinal microecological changes and its pathogenesis in sepsis,as well as the progress of treatment.