肠道微生态与儿童炎症性肠病

Intestinal microbiota and pediatric inflammatory bowel disease

炎症性肠病是一种原因不明的慢性复发性肠道炎症性疾病,目前认为是由易感基因、肠道微生态及免疫参与等多种因素共同介导,三者之间相互影响、相互作用,导致肠道微环境被破环,影响宿主的免疫耐受,最终诱发肠道炎症。本文就肠道微生态在炎症性肠病患儿中的作用机制进行总结,探讨微生态制剂对于炎症性肠病患儿个体化治疗的新思路。

Inflammatory bowel disease is a chronic recurrent inflammatory disease of the intestine of unknown origin.It is currently thought to be mediated by a combination of susceptibility genes,intestinal microecology and immune involvement,with all three interacting and influencing each other.This leads to a disruption of the intestinal microenvironment,which affects the host′s immune tolerance,and ultimately induces intestinal inflammation.In this review,we summarized the mechanisms of intestinal microbiota in children with inflammatory bowel disease and discussed new ideas of microecological agents for individualized treatment of children with inflammatory bowel disease.