益生菌与极早产儿近期临床结局的研究进展

Research progress on probiotics and short-term clinical outcomes in extremely premature infants

极早产儿存在不同程度的器官发育不成熟、肠道菌群建立异常和免疫功能低下,易出现坏死性小肠结肠炎、晚发型败血症等并发症。益生菌能改善肠道菌群,调节细胞代谢活性及免疫功能,可用于预防坏死性小肠结肠炎、晚发型败血症等。但使用益生菌对极早产儿可能的危害不能忽视。本文主要就目前国内外关于益生菌对极早产儿的作用作一综述,以更好地帮助极早产儿。

The extremely premature infants have different degrees of immature organ development,abnormal intestinal flora establishment and low immune function,and are prone to necrotizing enterocolitis,late-onset sepsis and other complications.Probiotics can improve intestinal flora,and regulate cell metabolic activity and immune function.Probiotics can be used to prevent necrotizing enterocolitis,and late-onset sepsis and so on.However,the possible harm of probiotics to extremely premature infants should not be ignored.This review summarized the effects of probiotics on extremely premature infants.