肠道菌群与多囊卵巢综合征并发抑郁症关系的研究进展

Relationship between intestinal flora and polycystic ovary syndrome complicated with depression:research progress

抑郁症是多囊卵巢综合征(polycystic ovary syndrome,PCOS)常并发的精神障碍性疾病,不仅严重影响PCOS患者的生活质量,还会进一步加重内分泌代谢的紊乱,形成恶性循环,增加治疗疾病的难度。目前临床上对PCOS并发抑郁症主要采用分开诊治的方案,并未根据两者之间内在的联系找到针对性的治疗药物。近年的研究表明,PCOS患者的肠道菌群存在明显失衡,而失衡的肠道菌群可通过“肠-脑轴”导致抑郁症的发生。因此肠道菌群与PCOS并发抑郁症的发生密切相关。本文就肠道菌群与PCOS并发抑郁症关系的研究进展进行综述,以期为临床上治疗PCOS并发抑郁症提供参考。

Depression is a mental disorder often associated with polycystic ovary syndrome(PCOS).It not only severely affects the quality of life of PCOS patients,but also aggravates endocrine and metabolism disorders,forming a vicious circle,and making the treatment of the disease more difficult.At present,PCOS complicated with depression is mainly treated separately in clinical practice,and no targeted treatment drugs have been found based on the intrinsic relationship between the two.Recent studies have shown that there is a significant imbalance in the intestinal flora of patients with PCOS,and the imbalance of intestinal flora can lead to the occurrence of depression through the"Gut-Brain Axis".Therefore,intestinal flora is closely related to the occurrence of PCOS complicated with depression.This article reviews the progress in research on the relationship between intestinal flora and PCOS complicated with depression,in order to provide reference for further clinical research on the treatment of PCOS complicated with depression.