甲泼尼龙联合丙卡特罗对支气管哮喘患者肺功能及炎症反应的影响

Effect of Methylprednisolone Combined with Procarterol on Lung Function and Inflammatory Response in Patients with Bronchial Asthma

目的探讨甲泼尼龙联合丙卡特罗对支气管哮喘患者肺功能及炎症反应的影响。方法选取2019年10月至2020年12月盘锦辽油宝石花医院收治的64例支气管哮喘患者作为研究对象,按随机数字表法分为对照组和观察组,各32例。对照组采用丙卡特罗治疗,观察组给予甲泼尼龙联合丙卡特罗。比较两组治疗效果、临床症状消失时间、肺功能、炎症因子、血气指标及安全性。结果观察组治疗有效率为93.75%,高于对照组65.63%,肺部哮鸣音、肺部湿啰音及咳嗽改善时间短于对照组,差异有统计学意义(P<0.05);治疗前,两组肺功能、炎症因子水平及血气指标比较,差异无统计学意义(P>0.05);治疗后,观察组第一秒钟用力呼气容积(FEV_(1))、最大呼气流量(PEF)、用力肺活量(FVC)水平高于对照组,白细胞介素-6(IL-6)、白细胞介素-7(IL-7)、白细胞介素-10(IL-10)水平低于对照组,动脉血二氧化碳分压(PaCO_(2))低于对照组,动脉血氧分压(PaO_(2))高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论甲泼尼龙联合丙卡特罗治疗支气管哮喘患者可有效缩短临床症状消失时间,改善肺功能,调节炎症因子水平及血气指标,且具有较高安全性。

Objective To explore the effect of methylprednisolone combined with proterol on lung function and inflammatory response in patients with bronchial asthma.Methods 64 bronchial asthma patients admitted to Panjin Liaoyou Baobaohua Hospital from October 2019 to December 2020 were divided into 32 each by randomized digital table.The control group was treated with prenatro tablets,and the observation group was administered prednisolone plus prenatone.Comparing the two groups of treatment effect,disappearance time of clinical symptoms,lung function,inflammatory factors,blood gas indicators and safety.Results The treatment efficiency of the observation group was 93.75%,higher than in the control group,65.63%,Lung wheezing,lung wet rale,and cough improvement times were shorter than in the control group,the difference was statistical significant(P<0.05);pretherapy,Comparison of lung function,inflammatory factors level and blood gas index between the two groups,the difference was not significantly significant(P>0.05);post-treatment,The first-second forced expiratory volume(FEV_(1)),maximum expiratory flow rate(PEF),and forced expiratory volume(FVC)levels were all higher than those in the control group,Interleukin-6(IL-6),interleukin-7(IL-7),and interleukin-10(IL-10)levels were all lower than those in the control group,Arterial blood carbon dioxide partial pressure(PaCO_(2))was lower than in the control group,Arterial oxygen partial pressure(PaO_(2))was higher than in the control group,The difference was statistical significant(P<0.05);Comparison of adverse effects incidence between the two groups,no statistical difference(P<0.05).Conclusion The treatment of methylprednisolone combined with proterol can effectively shorten the disappearance time of clinical symptoms,improve lung function,regulate inflammatory factors level and blood gas index,and have high safety.