美浮特^(■)皮肤抗菌液联合菲嘉^(■)皮肤抗菌液治疗甲真菌病的临床研究

Efficacy and safety of Meifute^(■) antifungal solution combined with Feijia^(■) antifungal solution in the treatment of onychomycosis

目的观察美浮特^(■)皮肤抗菌液联合菲嘉^(■)皮肤抗菌液治疗甲真菌病的疗效及安全性。方法从2020年12月至2022年11月于浮美连锁门诊入组120例患者进行治疗。先以美浮特^(■)皮肤抗菌液泡足治疗,再以菲嘉^(■)皮肤抗菌液泡甲治疗每周1次,常规治疗28周,最后再给予1次美浮特^(■)皮肤抗菌液巩固治疗。以治疗前后病甲改变情况评估疗效,记录不良事件,并于疗程完成后进行治疗满意度问卷调查。结果112例患者完成研究,共纳入病甲588个。疗效及满意度:总有效率58.0%(341/588),痊愈率20.6%(121/588),患者总体满意度为93.8%(105/112)。安全性:不良反应均为局部症状,如甲下出血(2例)、甲周脱皮(4例)、皮肤轻度红肿(6例)、轻到中度的烧灼感或刺痛感(16例),所有患者均可耐受治疗过程,未发生严重不良反应。结论美浮特􀆿皮肤抗菌液联合菲嘉^(■)皮肤抗菌液治疗甲真菌病操作简便、疗效显著、安全性好、依从性高,不失为一种临床可选择的甲真菌病治疗方法。

Objective To evaluate the efficacy and safety of Meifute^(■)􀆿antifungal solution combined with Feijia^(■) antifungal solution in the treatment of onychomycosis.Methods From December 2020 to November 2022,120 patients were enrolled in Fumei Outpatient Departments for this study.First of all,a single-session soak in Meifute^(■)􀆿antifungal solution was used to treat tinea pedis;and then,diseased nails were treated with Feijia^(■)antifungal solution once a week for 28 weeks routinely;finally,another time of Meifute^(■)antifungal solution treatment was given to consolidate the effect.Efficacy and safety evaluation was performed after treatment,and a questionnaire survey of treatment satisfaction was carried out after the completion of the treatment course.Results Finally 112 patients completed the study and 588 nails were included.Efficacy and satisfaction:overall effective rate was 58.0%(341/588),the cure rate was 20.6%(121/588),and the comprehensive satisfactory rate was 93.8%(105/112).The efficacy of the first toenail(52.9%)was lower than that of other toenails(60.7%).And there was no significant difference in the clinical response rate between DLSO(56.6%)and TDO(61.4%).Safety:The adverse reactions were all local symptoms,such as subungual hemorrhage(2 cases),exfoliation of epidermis around nails(4 cases),mild redness and swelling of skin(6 cases),mild to moderate burning or tingling(16 cases)after soak.All patients could tolerate the process without serious adverse reactions.Conclusion The use of Meifute􀆿antifungal solution combined with Feijia􀆿antifungal solution is simple,effective,safe,and highly compliant in the treatment of onychomycosis,so it can be regarded as a clinical alternative treatment for onychomycosis.