中药多糖调节肠道菌群治疗2型糖尿病研究进展

Research Progress in Treatment of Type 2 Diabetes by RegulatingIntestinal Flora with Polysaccharide of Chinese Medicine

糖尿病是一种严重威胁人类健康的慢性代谢疾病,2型糖尿病(type 2 diabetes mellitus,T2DM)是最常见的糖尿病类型,其发展受到多种遗传因素和环境因素影响。肠道菌群近年来被证实是影响肥胖、T2DM等代谢疾病进程的重要因素。多项研究表明中药多糖可通过调节肠道菌群治疗T2DM。然而,T2DM患者的肠道菌群特征及中药多糖通过肠道菌群治疗T2DM的机制均尚未明确。通过综述近年来中药多糖调节肠道菌群治疗T2DM相关研究成果,为中药多糖与肠道菌群的相互作用研究提供参考,为中药多糖治疗T2DM作用机制的阐明提供理论依据。

Diabetes is a chronic metabolic disease that seriously threatens human health.Type 2 diabetes(T2DM)is the most common type of diabetes,and its development is affected by a variety of genetic and environmental factors.In recent years,intestinal flora has been proved to be an important factor affecting the process of metabolic diseases such as obesity and T2DM.Many studies have shown that Chinese herbal polysaccharides can treat T2DM by regulating intestinal flora.However,the characteristics of intestinal flora in T2DM patients and the mechanism of Chinese herbal polysaccharide treating T2DM through intestinal flora are not clear.By reviewing the research results of the regulation of intestinal flora by Chinese herbal polysaccharides in the treatment of T2DM in recent years,it provides a reference for the study of the interaction between Chinese herbal polysaccharides and intestinal flora,and provides a theoretical basis for the elucidation of the mechanism of action of Chinese herbal polysaccharides in the treatment of T2DM.