从COVID-19与肠道菌群关系探讨中医药治疗的潜在作用机制

Potential Mechanism of Chinese Medicine Treatment from Relationship Between COVID-19 and Intestinal flora

新型冠状病毒肺炎(COVID-19)仍肆虐全球,尚未研发出针对COVID-19的特效药。疫情伊始,我国对COVID-19患者积极采用中医药疗法,效果显著。大量临床证据表明,COVID-19患者普遍存在肠道菌群失调症,且与不良预后相关,而对肠道菌群进行有效干预可以一定程度上改善其临床症状。中医药(如金花清感颗粒、连花清瘟颗粒(胶囊)、血必净注射液、清肺排毒汤、麻杏石甘汤)治疗COVID-19已被临床实践证明是安全有效的,而组方中共有的中药如甘草、金银花、黄芩、黄芪等对肠道菌群、免疫系统和血管紧张素转化酶2均有一定的调节作用。更重要的是,清肺排毒汤、麻杏石甘汤和血必净注射液已被证实可以调节肠道菌群。据此,我们提出肠道菌群可能是中医药防治COVID-19及其并发症的重要“靶点”。

COVID-19 is still rampant around the world,and no specific drug has been developed for it.At the beginning of the epidemic,China actively adopted Chinese medicine treatment for COVID-19 patients,with remarkable results.A large amount of clinical evidence shows that COVID-19 patients generally have intestinal flora disorder,which is related to poor prognosis,and effective intervention of intestinal flora can improve their clinical symptoms to a certain extent.Traditional Chinese medicine(such as Jinhua Qinggan Granule,Lianhua Qingwen Granule(capsule),Xuebijing Injection,Qingfei Detox Decoction,Maxing Shigan Decoction)has been proved to be safe and effective in the treatment of COVID-19 by clinical practice,while the traditional Chinese medicine commonly used in the formula,such as Licorice,Honeysuckle,Scutellaria baicalensis,and Astragalus membranaceus,have certain regulatory effects on intestinal flora,immune system and angiotensin converting enzyme 2.More importantly,Qingfei Jiedu Decoction,Maxing Shigan Decoction and Xuebijing Injection have been proved to regulate intestinal flora.It is suggested that intestinal flora may be an important“target”for the prevention and treatment of COVID-19 and its complications by traditional Chinese medicine.