中药抑制结肠癌血管生成的作用机制研究进展

Research progress on mechanism of traditional Chinese medicine inhibiting colon cancer angiogenesis

结肠癌是一种最常见的消化道恶性肿瘤,血管生成是其发生发展的重要机制之一。现代研究证实,中药可通过抑制促血管生成因子表达、抑制血管内皮细胞增殖及诱导其凋亡和调节相关信号通路等抑制血管新生,对于结肠癌的治疗具有独特优势。总结中药抑制结肠癌血管生成的相关文献,梳理主要作用机制,以期为临床结肠癌治疗策略的优化提供借鉴与参考。

Colon cancer is one of the most common gastrointestinal malignancies, and angiogenesis is one of the important mechanisms of its occurrence and development. Modern studies have confirmed that traditional Chinese medicine can inhibit the angiogenesis by inhibiting the expression of angiogenic factor, inhibiting the proliferation of vascular endothelial cell, inducing their apoptosis and regulating related signaling pathways, which has unique advantages for the treatment of colon cancer. The relevant literatures on inhibition of colon cancer angiogenesis by traditional Chinese medicine were summarized, and the main mechanism of action was sorted out, with view to providing reference for optimization of clinical colon cancer treatment strategy in clinic.