摘要
姜黄素是一种脂溶性多酚类化合物,目前有多项姜黄素治疗慢性肾脏病的临床试验。检索了姜黄素治疗肾脏纤维化的相关研究,从抑制炎症反应、抗氧化应激和抑制肾小管上皮细胞-间充质转变等分子机制方面归纳总结了姜黄素治疗肾间质纤维化的重要信号通路,以期为其进一步研究和开发提供借鉴。
Curcumin is a fat-soluble polyphenolic compound. At present, there are several clinical trials of curcumin in treatment of chronic kidney disease. Relevant researches on curcumin in treatment of renal fibrosis were searched, the important signaling pathways of curcumin in treatment of renal interstitial fibrosis were summarized from the molecular mechanisms of inhibiting inflammatory response, anti-oxidative stress and inhibiting renal tubular epithelial-mesenchymal transition in this paper, in order to provide reference for its further research and development.
作者
陈欠欠
朱凤阁
陈香美
CHEN Qian-qian;ZHU Feng-ge;CHEN Xiang-mei(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Nephrology Institute of the Chinese People's Liberation Army,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Disease Research,Department of Nephrology,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第3期966-975,共10页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(32141005)
北京市科技计划项目(D18110700010000)。
关键词
姜黄素
慢性肾脏病
肾间质纤维化
抗炎
氧化应激
上皮细胞-间充质转变
curcumin
chronic kidney disease
renal interstitial fibrosis
anti-inflammation
oxidative stress
epithelial-mesenchymal transition
