毛诃子化学成分和药理作用的研究进展及其质量标志物(Q-Marker)预测分析

Research progress on chemical constructions and pharmacological effects of Terminaliae Belliricae Fructus and predictive analysis of its quality markers

毛诃子Terminaliae Belliricae Fructus为藏族习用药材,在传统中医药以及多民族医药中使用广泛且悠久。现代研究表明毛诃子主要含有酚酸类、鞣质类、黄酮类、萜类、甾体类、木脂素类等化学成分,具有保肝、降血糖、调血脂与抗肿瘤等药理作用。基于对毛诃子的化学成分及药理作用的归纳总结,结合其质量控制研究现状,从传统药性、传统功效、化学成分可测性及药动学等方面对其质量标志物(quality marker,Q-Marker)进行预测。没食子酸、鞣花酸、柯里拉京、没食子甲酯、诃子鞣酸、单宁酸、奎宁酸、6-姜酚、儿茶素等成分可作为毛诃子的主要Q-Marker,以期为毛诃子进一步研究及质量标准的合理建立提供参考。

Maohezi(Terminaliae Belliricae Fructus) is a commonly used herb in Tibetan medicine. It is widely used in traditional Chinese medicine and multi-ethnic medicine with long history. Modern researches have shown that it mainly contains phenolic acids,tannins, flavonoids, terpenoids, steroids, lignans and other chemical components, with hepatoprotective, hypoglycemic activity, blood lipids regulation and antitumor pharmacological effects. Based on a summary of the chemical constituents and pharmacological effects of Terminaliae Belliricae Fructus, combining with the research progress of its quality control, Q-Marker predictions were made in terms of traditional medicinal properties, traditional efficacy, chemical constituents measurability and pharmacokinetics. Gallic acid,ellagic acid, corilagin, methyl gallate, chebulinic acid, tannic acid, quinic acid, 6-gingerol and catechins can be used as the main QMarker of Terminaliae Belliricae Fructus, in order to provide a reference for further research and rational establishment of quality standards of Terminaliae Belliricae Fructus.