黄芪甲苷抗肿瘤作用机制研究进展

Research progress on antitumor mechanism of astragaloside Ⅳ

黄芪甲苷是从黄芪Astragali Radix中提取得到的皂苷类化合物,是黄芪的主要有效成分之一,具有抗炎、抗氧化、免疫调节、调节代谢及抗肿瘤等药理作用,近年来在抗肿瘤领域备受关注。研究发现黄芪甲苷能抑制肿瘤细胞增殖,进一步抑制肺癌、结直肠癌、肝癌、宫颈癌、卵巢癌等癌症进展。其抗肿瘤作用机制主要有抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、阻滞细胞周期进程、抑制肿瘤细胞侵袭等,此外还发现黄芪甲苷能在一定程度上增强抗肿瘤药物敏感性和提高机体免疫力。黄芪甲苷可通过多种途径发挥抗肿瘤作用,在抗肿瘤治疗领域有广阔的应用前景。对其抗肿瘤作用及机制进行综述,以期为临床的肿瘤治疗提供新的理论支持与借鉴。

Astragalus Ⅳ is the saponin compound extracted from Huangqi(Astragali Radix), which is one of the main active ingredients from Astragali Radix. It has a wide range of pharmacological effects such as anti-inflammatory, anti-oxidant, immune regulation, metabolism regulation and antitumor, and has attracted much attention in the field of antitumor in recent years. It was found that astragaloside Ⅳ can inhibit the proliferation of tumor cells and further inhibit the progression of cancers such as lung cancer,colorectal cancer, liver cancer, cervical cancer, and ovarian cancer. The antitumor mechanism of astragaloside Ⅳ mainly includes inhibiting tumor cell proliferation, promoting tumor cell apoptosis, blocking cell cycle process, inhibiting tumor cell invasion, etc. In addition, it was also found that astragaloside Ⅳ can enhance the sensitivity of antitumor drugs and improve the body immunity to a certain extent. Astragaloside Ⅳ can exert antitumor effects through various ways, and has broad application prospects in the field of antitumor therapy. This paper reviews the antitumor effects and mechanisms of astragaloside Ⅳ, in order to provide new theoretical support and reference for clinical antitumor therapy.