牛蒡多糖调控糖脂代谢的研究进展

Research progress of Arctium lappa polysaccharide on regulation of glycolipid metabolism

糖脂代谢紊乱与肥胖、非酒精性脂肪肝、高血压、高血脂、糖尿病、动脉粥样硬化、癌症等疾病的发生发展密切相关。多糖是重要的天然活性物质,具有很大的开发潜力,尤其是在抗氧化、抗炎、抗癌、调脂等方面引起国内外学者的高度关注。牛蒡多糖是药食同源植物牛蒡Arctium lappa中重要的活性成分之一,近年来被发现具有调节机体脂质代谢、抗氧化、抗炎和调节肠道菌群等多种功能,能预防和改善肥胖、糖尿病和心血管疾病等代谢综合征,是牛蒡改善糖脂代谢紊乱的物质基础。综述了牛蒡多糖在调控糖脂代谢的有益作用,并探讨其潜在的作用机制,以期为牛蒡多糖防治肥胖及相关代谢疾病提供依据,并为牛蒡的开发利用提供新思路。

The disorder of glycolipid metabolism is closely related to the occurrence of obesity,nonalcoholic fatty liver disease,hypertension,hyperlipidemia,diabetes,atherosclerosis,cancer,and other diseases.Polysaccharides are important natural bioactive substances with great potential development and utilization values,especially in anti-oxidation,anti-inflammation,anti-cancer,lipid regulation,and others,which had attracted great attention from scholars at home and abroad..Arctium lappa is a medicinal and edible homologous plant and the polysaccharides in it is one of the important bioactive ingredients.In recent years,burdock polysaccharide had been found to have multiple functions such as regulating body lipid metabolism,anti-oxidation,anti-inflammatory,regulating intestinal microflora,and so on,and prevent and improve metabolic syndrome such as obesity,diabetes,and cardiovascular disease,which is the substance basis for improving the disorder of glycolipid metabolism.This review summarizes the beneficial effects of burdock polysaccharides in the regulation of glycolipid metabolism,as well as its potential mechanism of action,in order to provide a theoretical basis for burdock polysaccharides in prevention and treatment of obesity and relative metabolic diseases,and to give a new strategy for the development and utilization of burdocks.