白藜芦醇通过调控信号通路治疗膝骨关节炎的研究进展

Research progress on resveratrol in treatment of knee osteoarthritis by regulating signaling pathway

膝骨关节炎(knee osteoarthritis,KOA)为一种慢性退行性病变,可导致关节功能减退、丧失,严重影响人类生活质量。白藜芦醇是一种天然多酚类植物抗毒素,是虎杖等药用植物中的主要活性成分,具有保护血管、抗炎、抗癌、抗氧化等作用,可通过调控核因子E2相关因子2/血红素氧合酶-1/醌氧化还原酶1信号通路、Toll样受体4/髓样分化因子88信号通路、磷酯酰肌醇3-激酶/蛋白激酶B信号通路、核因子-κB信号通路、酪氨酸激酶2/转录激活因子3信号通路、分泌型糖蛋白/β-连环蛋白信号通路等发挥抗KOA作用。通过对白藜芦醇调控信号通路治疗KOA的分子机制进行综述,为合理应用及药物开发提供依据。

Knee osteoarthritis is a chronic degenerative diseases, which can lead to joint dysfunction and loss, and seriously affect the quality of human life. Resveratrol is a natural polyphenol plant antitoxin, and is the main active ingredient of Huzhang(Polygonum cuspidatum Sieb. et Zucc.), which has vascular protection, anti-inflammatory, anti-cancer and antioxidant effects. Anti-knee osteoarthritis can be induced by regulating nuclear factor erythroid-2-related factor 2/hemeoxygennase-1/NADPH qunineoidoreductase 1 signaling pathway, Toll like receptor 4/myeloid differentiation factor 88 signaling pathway, phosphatidylinositol-3-kinase/protein kinase B signaling pathway, nuclear factor-κB signaling pathway, Janus kinase 2/signal transducer and activator of transcription 3signaling pathway, Wnt/β-catenin signaling pathway. This paper reviews the molecular mechanism of resveratrol regulating signaling pathway in the treatment of knee osteoarthritis, and provides the basis for its rational application and drug development.