TREMble Before TREM2:The Mighty Microglial Receptor Conferring Neuroprotective Properties in TDP-43 Mediated Neurodegeneration

Microglia were long hailed as solely infammatory cells,and though they are responsible for the brain's immuneresponse,they perform a variety of neuroprotective func-tions including the clearance of cellular and toxic debris^([1]).One toxic molecule known to be cleared by microglia isthe protein aggregate found in Alzheimer's Disease(AD),amyloid-B.