中国无偿献血人群HEV感染标志物流行率的Meta分析

Prevalence of HEV infection markers in Chinese blood donors:a meta-analysis

目的分析我国各地无偿献血人群中HEV感染血清学标志物及RNA流行率情况,为针对无偿献血者HEV筛查必要性及制定筛查策略提供基础数据。方法根据关键词检索中国知网、万方医学、PubMed等数据库,提取符合纳入标准的文献数据,运用R4.1.3软件进行Meta分析。结果1)获得符合纳入标准的文献共26篇,抗-HEV IgG、抗-HEV IgM、HEV RNA分别调查97928、117831、82673例;2)中国无偿献血人群中抗-HEV IgG合并流行率为23.0%[95%CI(18%,29%)],且不同城市和地区之间存在显著性差异;3)中国无偿献血人群中抗-HEV IgM合并流行率为1.13%[95%CI(0.94%,1.36%)],且不同城市和地区之间存在显著性差异;4)中国无偿献血者HEV RNA合并流行率为0.028%[95%CI(0.006%,0.059%)],且不同城市和地区之间存在显著性差异。结论中国无偿献血者人群中HEV既往感染率较高,且呈现显著的地域分布差异;现症感染率相对较低且较前十年有所降低,但仍存在输血残余风险,需加强对无偿献血者血液HEV筛查的重视。

Objective To analyze the serological markers and RNA prevalence of HEV infection in Chinese voluntary blood donors in different regions of China,so as to provide basis for the necessity of HEV screening and the formulation of screening strategies for voluntary blood donors.Methods Databases such as CNKI,Wanfang medicine and PubMed were searched for eligible literature,and the literature data meeting the inclusion criteria were extracted for meta-analysis using R4.1.3 software.Results A total of 26 studies were included,involving 97928,117831 and 82673 cases,respectively,for anti-HEV IgG,anti-HEV IgM and HEV RNA.The pooled estimated prevalence of anti-HEV IgG,anti-HEV IgM and HEV RNA among Chinese voluntary blood donors was 23.0%[95%CI(18%,29%)]vs 1.13%[95%CI(0.94%,1.36%)]vs 0.028%[95%CI(0.006%,0.059%)],and there were significant differences among different cities and regions.Conclusion The past infection rate of HEV among voluntary blood donors in China was somewhat high and with significant regional differences.The current infection rate was relatively low and had decreased compared with that in the past decade,but there was still residual risk of blood transfusion.It is necessary to pay more attention to blood HEV screening of voluntary blood donors.