基于“肠道菌群”探讨从脾论治年龄相关性黄斑变性的科学内涵

To explore the scientific connotation of treating age-related macular degeneration from spleen based on"intestinal flora"

随着我国人口老龄化程度渐剧,年龄相关性黄斑变性(AMD)的发病率呈逐年上升的趋势,已成为老年人视力损伤的主要原因之一,而中医药在防治AMD中发挥着日益重要的作用。其中,基于陈达夫教授创立的“眼科六经辨证”学说,从脾论治AMD取得良好的疗效,但其作用机制尚未完全明确。现有研究表明,AMD的发生、发展与肠道菌群紊乱有关,而中医学认为,脾脏在维持肠道菌群的稳态中发挥着重要作用,且脾脏与肠腑关系密切,二者协调共用。故本文基于肠道菌群理论,结合现有研究成果,阐述脾脏与AMD之间的联系,探讨从脾论治AMD的作用机制,以期为其进一步的推广及应用提供科学依据。

With the gradual aging of the population in China,the incidence of age-related macular degeneration(AMD)is increasing year by year,which has become one of the main causes of visual impairment in the elderly,and Traditional Chinese Medicine(TCM)plays an increasingly important role in the prevention and treatment of AMD.Among them,based on Professor CHEN Dafu's theory of six-meridian syndrome differentiation in ophthalmology,a good effect has been achieved in the treatment of age-related macular degeneration from the theory of spleen,but its mechanism is not completely clear.Existing studies have shown that the occurrence and development of age-related macular degeneration is related to the disorder of intestinal flora,while TCM believes that the spleen plays an important role in maintaining the homeostasis of intestinal flora,and there is a close relationship between spleen and intestines.Therefore,based on the theory of intestinal flora,combined with the existing research results,this paper expounds the relationship between spleen and AMD,and discusses the mechanism of spleen in the treatment of AMD,in order to provide scientific basis for its further promotion and application.