1990年与2019年中国0~14岁儿童肿瘤疾病负担分析

Disease burden of tumors among children aged 0 to 14 years in China in 1990 and 2019

目的了解1990年与2019年中国0~14岁儿童肿瘤疾病负担,为中国儿童肿瘤防控提供依据。方法通过全球健康交流数据库收集2019年全球疾病负担资料,采用死亡率、伤残调整寿命年(DALY)率分析1990年与2019年中国0~14岁儿童肿瘤疾病负担,并与全球不同社会人口指数(SDI)地区进行比较。结果中国0~14岁儿童肿瘤死亡率由1990年的13.10/10万降至2019年的4.96/10万,DALY率从1118.93/10万降至424.77/10万,降幅分别为62.17%和62.04%。男童肿瘤死亡率从13.48/10万降至5.38/10万,DALY率从1147.09/10万降至458.65/10万;女童肿瘤死亡率从12.69/10万降至4.46/10万,DALY率从1088.22/10万降至384.94/10万。儿童肿瘤疾病负担集中在0~4岁。2019年白血病、脑和神经系统肿瘤、淋巴瘤居儿童肿瘤疾病负担的前三名。与全球不同SDI地区比较,中国0~14岁儿童肿瘤死亡率和DALY率下降幅度最大,但仍高于中等SDI、中高SDI、高SDI地区。结论与1990年相比,2019年中国0~14岁儿童肿瘤疾病负担有所下降,但仍高于中等及以上SDI地区。0~4岁儿童、男童的疾病负担相对较重;主要肿瘤类型为白血病、脑和神经系统肿瘤、淋巴瘤。

Objective To investigate trends in the disease burden of tumors among children aged 0 to 14 years in China in 1990 and 2019,so as to provide insights into management of pediatric tumors in China.MethodsThe Global Burden of Disease 2019 data were retrieved from the Global Health Data Exchange,and the mortality and dis-ability adjusted life years(DALYs)of pediatric tumors were evaluated among children at ages of 0 to 14 years in Chi-na in 1990 and 2019,and the disease burdens due to pediatric tumors in China were compared with the regions with different social population index(SDI).ResultsThe mortality of tumors decreased from 13.10/10~5in 1990 to 4.96/10~5in 2019(a 62.17%reduction)among children aged 0 to 14 years in China,and the DALY rate decreased from1118.93/10~5to 424.77/10~5(a 62.04%reduction).The mortality and DALY rate of tumors decreased from 13.48/10~5to5.38/10~5,and from 1147.09/10~5to 458.65/10~5among male children,and from 12.69/10~5to 4.46/10~5,and from 1088.22/10~5to 384.94/10~5among female children.The disease burden of pediatric tumors was concentrated among children at ages of 0 to 4 years.The three highest disease burdens of pediatric tumors were measured in leukemia,brain and nerve sys-tem tumors,and lymphoma in 2019.Compared with the regions with different SDI,the largest reductions were seen in the mortality and DALY rate of tumors among children at ages of 0 to 14 years in China,which were still higher than in middle,high-middle and high SDI regions.ConclusionsThe disease burden of tumors declined among children at ages of 0 to 14 years in China in 2019,compared with 1990;however,it is still higher than in middle and higher SDI regions.The disease burden of pediatric tumors was high among children at ages of 0 to 4 years and among male children,with leukemia,brain and nerve system tumors and lymphoma as predominant types.