重构本草——钩藤

Reconstruction of Chinese materia medica-gambir plant nod

通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内专家学者的认识及应用经验,经讨论认为钩藤:功效主要为息风定惊,清热平肝;症靶为热性惊厥和小儿夜啼;标靶为高血压;现代药理发现,钩藤及其有效成分具有降低血压、改善帕金森病、抗抑郁、改善脑缺血/再灌注损伤、改善胰岛素抵抗、抗肿瘤等作用;本品无毒,但是脾胃虚寒者慎服;临床使用剂量为6〜30g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索钩藤用量与症靶、标靶的量效关系构建.

Based on the investigation of ancient books and literature,the progress and achievements of modern research on traditional Chinese medicine,and the understanding and application experience of experts and scholars in the field of clinical Chinese medicine and Chinese material medica,it is believed that gambir plant nod has the following characteristics:Its effects are mainly to calm endogenous wind and arrest convulsions,clear heat and suppress hyperactive liver.Its symptom targets are febrile convulsion and morbid night crying of babies,while its biochemical indicator target is high blood pressure.According to modem pharmacology,gambir plant nod and its effective components can play the roles of lowering blood pressure,ameliorating Parkinson disease symptoms,anti-depression,improving cerebral ischemia/reperfusion injury,ameliorating insulin resistance,anti-tumor,etc.With non-toxic effects,it also should be taken with caution for those with the syndrome of deficient cold of the spleen and stomach.Its clinical dosage range is 6-30g.When taken orally,it should be used according to different diseases or different stages of the same disease,and an effort should be made to actively explore the construction of the dose-effect relationship between its dosage and its symptom targets or biochemical indicator targets.