慢性阻塞性肺疾病合并肌少症的发病机制

Pathogenesis of sarcopenia in chronic obstructive pulmonary disease

肌少症是以多系统衰退为特征的老年综合征,主要反映在骨骼肌功能障碍上。骨骼肌功能障碍普遍存在于慢性阻塞性肺疾病(COPD)的所有阶段,并对患者的重要临床结果产生负面影响。近年来,多种因素被提出影响COPD患者的骨骼肌功能障碍,包括蛋白质合成和分解代谢失衡、全身炎症反应、氧化应激、低氧、高碳酸血症、激素代谢水平异常、活动减少、营养不良、维生素D缺乏等,导致肌肉工作能力下降。本文就COPD合并肌少症可能的发病机制的研究进展进行综述。

Sarcopenia is geriatric syndromes characterized by multisystem decline, which is mainly reflected in skeletal muscle dysfunction.Skeletal muscle dysfunction is prevalent in all stages of chronic obstructive pulmonary disease(COPD)and negatively affects important clinical outcomes for patients.In recent years, multiple factors have been proposed to influence muscle dysfunction in COPD patients, including the imbalance between protein synthesis and catabolic, systemic inflammation, oxidative stress, hypoxia, hypercapnia, hormone metabolism abnormal, decrease activities, malnutrition, Vitamin D deficiency and so on, resulting in a decrease in the muscle’s ability to work.This article reviews the research progress of possible pathogenesis of sarcopenia in COPD.