血必净联合纤维支气管镜吸痰灌洗治疗重症肺炎的疗效及对血清炎性因子水平的影响

Effect of Xuebijing Combined with Fiberoptic Bronchoscope Sputum Lavage on Severe Pneumonia and its Effect on Serum Inflammatory Factors

目的 研究血必净联合纤维支气管镜吸痰灌洗治疗方法对重症肺炎患者所发挥的临床治疗效果,并分析对患者血清炎性因子水平的影响。方法 选择2019年4月至2020年5月来我院接受治疗的92例重症肺炎患者分为观察组和对照组,每组患者46例。对照组患者单纯应用纤维支气管镜吸痰灌洗治疗,观察组在对照组基础上配合血必净治疗,对两组患者不同治疗以后的治疗总有效率、并发症发生率、血氧分压、动脉血二氧化碳分压、血氧饱和度、血清TNF-α、CRP等指标、生活质量评分进行比较。结果 观察组(43例,占比为93.48%)经过治疗后的治疗有效率明显高于对照组(37例,占比为80.43%),差异有统计学意义(P <0.05)。观察组(5例,占比为10.87%)治疗后的并发症发生率和对照组(3例,占比为6.52%)相比差异无统计学意义(P> 0.05)。两组患者治疗前的血氧分压、动脉血二氧化碳分压、血氧饱和度、血清TNF-α、CRP等差异无统计学意义(P> 0.05);治疗后,观察组患者的血氧分压、动脉血二氧化碳分压、血氧饱和度、血清TNF-α、CRP等改善效果比对照组更理想,差异有统计学意义(P <0.05)。治疗前,两组患者生活质量差异无统计学意义(P> 0.05);治疗后,观察组患者的生活质量改善效果比对照组更理想,差异有统计学意义(P <0.05)。结论 通过血必净联合纤维支气管镜吸痰灌洗治疗重症肺炎的患者能在确保安全的前提之下提升患者治疗的总有效率,对改善患者的动脉血气指标、血清炎性因子发挥了重要作用,还能提升患者的生活质量。

Objective To study the clinical effect of Xuebijing combined with fiberoptic bronchoscope suction lavage on patients with severe pneumonia, and to analyze the effect on serum inflammatory factor levels. Methods A total of 92 patients with severe pneumonia who came to our hospital for treatment from April 2019 to May 2020 were selected and divided into an observation group and a control group, with an average of 46patients in each group. Patients in the control group were treated with fiberoptic bronchoscopic aspiration and lavage alone, the observation group was combined with Xuebijing treatment on the basis of the control group, and the total effective rate, complication rate, blood oxygen partial pressure,arterial blood carbon dioxide partial pressure, blood oxygen saturation, serum TNF-α, CRP and other related indicators, quality of life scores, etc.after different treatments were compared in the two groups. Results The effective rate of treatment in the observation group(43 cases, accounting for 93.48%) after treatment was significantly higher than that in the control group(37 cases, accounting for 80.43%)(P<0.05). The incidence of complications after treatment in the observation group(5 cases, accounting for 10.87%) was not significantly different from that in the control group(3 cases, accounting for 6.52%)(P>0.05). Before treatment, there were no significant differences in blood oxygen partial pressure, arterial blood carbon dioxide partial pressure, blood oxygen saturation, serum TNF-α and CRP(P>0.05). After treatment, the improvement effect of blood oxygen partial pressure, arterial blood carbon dioxide partial pressure, blood oxygen saturation, serum TNF-α and CRP in the observation group was more ideal than that in the control group(P<0.05). Before treatment, there was no significant difference in the quality of life between the two groups(P>0.05). After treatment, the improvement of quality of life in the observation group was more satisfactory than that in the control group(P<0.05).Conclusion Xuebijing combined with fiberoptic bronchoscopy for sputum suction and lavage in the treatment of patients with severe pneumonia can improve the overall effective rate of the patient’s treatment under the premise of ensuring safety, and play an important role in improving the patient’s arterial blood gas level and serum inflammatory factor levels. It can also improve the quality of life of patients.