紧急宫颈环扎术联合吲哚美辛、黄体酮阴道缓释凝胶治疗宫颈功能不全的临床效果观察

Clinical Observation of Emergency Cervical Cerclage Combined with Indomethacin and Progesterone Vaginal Sustained-release Gel in the Treatment of Cervical Insufficiency

目的 探讨紧急宫颈环扎术联合吲哚美辛、黄体酮阴道缓释凝胶治疗宫颈功能不全的临床效果。方法 选择2019年6月至2022年6月在淮安市妇幼保健院行紧急宫颈环扎术的52例患者资料作为分析对象,26例接受单纯紧急环扎术+吲哚美辛治疗作为对照组,26例接受紧急宫颈环扎术联合吲哚美辛、黄体酮阴道缓释凝胶治疗作为观察组,比较两组患者治疗成功率与延长孕周时间(周),药物不良反应发生率、新生儿Apgar评分的差异。结果 观察组治疗成功率高于对照组(P <0.05),延长孕周时间长于对照组(P <0.05);两组间不良反应发生率差异无统计学意义(P> 0.05);观察组新生儿Apgar评分高于对照组(P <0.05)。结论 紧急宫颈环扎术联合吲哚美辛、黄体酮阴道缓释凝胶治疗宫颈功能不全可以提高治疗成功率,改善妊娠结局,不增加不良反应发生率。

Objective To investigate the clinical effect of emergency cervical cerclage combined with indomethacin and progesterone vaginal sustained-release gel in the treatment of cervical insufficiency. Methods The data of 52 patients who underwent emergency cervical cerclage in Huai’an Maternal and Child Health Hospital from June 2019 to June 2022 were selected as the analysis objects. 26 patients received simple emergency cerclage+indomethacin treatment as the control group, and 26 patients received emergency cervical cerclage combined with indomethacin and progesterone vaginal sustained-release gel as the observation group the difference of Apgar score in neonates. Results The success rate of treatment of the observation group was higher than that of the control group(P<0.05), and the duration of pregnancy was longer than that of the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05);Apgar score of newborn of the observation group was higher than that of control group(P<0.05). Conclusion Emergency cervical cerclage combined with indomethacin and progesterone vaginal sustained-release gel in the treatment of cervical dysfunction can improve the success rate of treatment, improve pregnancy outcomes, and do not increase the incidence of adverse reactions.