探讨甲状腺切除手术的应用瑞芬太尼联合异丙酚麻醉的临床效果

To Explore the Clinical Effect of Remifentanil Combined with Propofol Anesthesia in Thyroidectomy

目的 试验将采用瑞芬太尼联合异丙酚麻醉协助甲状腺切除手术的治疗,分析临床应用成果。方法 试验选取了2019年1月至2020年7月收治的甲状腺切除手术患者作为研究的对象。通过回顾式分析对80例患者采用数字随机分组法,以公平性开展为前提进行分组调查。对照组患者采用异丙酚联合芬太尼开展麻醉措施,观察组则为瑞芬太尼联合异丙酚麻醉方案,对比患者的手术麻醉情况。结果 从麻醉质量上看,观察组患者在手术用时、自主恢复用时、拔管时间以及苏醒时间上分别为(1.20±0.30)h、(7.00±1.10)h、(8.40±0.50)h和(5.10±1.60)h,对照组对应为(1.40±0.80)h、(11.30±0.90)h、(14.30±2.70)h和(8.80±2.50)h,组间对比差异较为显著,具有统计学意义(P <0.05)。与此同时,在不良反应的调查上,观察组患者的发生率为5.00%(2/40),分别为1例咳血和1例低氧血症,明显低于对照组的12.50%(5/40),既包括3例低氧血症、1例咳血和1例镇静不足,对比差异具有统计学意义(P <0.05)。最后,调研患者对麻醉、手术情况的满意度,即观察组患者的满意评分为(92.60±3.50)分,对照组则为(87.10±2.80)分,差异具有统计学意义(P <0.05)。结论 异丙酚可以迅速的进入患者血液中,并被运输到中枢神经系统,从而发挥高效药剂作用,是亲脂性高的药物之一。而丙泊酚作为新型药物具有镇痛效果,能够帮助患者在一定时间内快速苏醒,能够满足手术操作的时间需求。采用瑞芬太尼联合异丙酚麻醉协助甲状腺切除手术效果显著,并能够控制不良反应时间,对于患者的手术顺利开展起到了推动作用。

Objective The experiment will use remifentanil combined with propofol anesthesia to assist in the treatment of thyroidectomy, and analyze the clinical application results. Methods From January 2019 to July 2020, patients who underwent thyroidectomy were selected as the subjects of study. Through retrospective analysis, 80 patients were randomly divided into groups with the premise of fairness. Patients in the control group were anesthetized with propofol and fentanyl, while those in the observation group were anesthetized with remifentanil and propofol.Results In terms of anesthesia quality, the patients in the observation group were(1.20±0.30) h,(7.00±1.10) h,(8.40±0.50) h and(5.10±1.60) h in terms of operation time, self recovery time, extubation time and recovery time, respectively, while the patients in the control group were(1.40±0.80) h,(11.30±0.90) h,(14.30±2.70) h and(8.80±2.50) h, with significant differences in comparison(P<0.05). At the same time, the incidence of adverse reactions in the observation group was 5.00%(2/40), which was 1 case of hemoptysis and 1 case of hypoxemia, significantly lower than 12.50%(5/40) in the control group, including 3 cases of hypoxemia, 1 case of hemoptysis and 1 case of sedation deficiency. The difference was statistically significant(P<0.05). Finally, the satisfaction of patients with anesthesia and operation was investigated, that is to say, the satisfaction score of patients in the observation group was(92.60±3.50), while that in the control group was(87.10±2.80), the difference was statistically significant(P<0.05).Conclusion Propofol can rapidly enter into the blood of patients and be transported to the central nervous system, so as to play a high-efficiency pharmaceutical role. It is one of the drugs with high lipophilicity. As a new drug, propofol has analgesic effect, can help patients wake up quickly in a certain period of time, and can meet the needs of operation time. Remifentanil combined with propofol anesthesia assisted thyroidectomy has a significant effect, and can control the time of adverse reactions, which plays a role in promoting the smooth operation of patients.