血管平滑肌细胞表型对动脉粥样硬化斑块稳定性的影响

Effects of Vascular Smooth Muscle Cells on Atherosclerotic Plaque Stability

血管平滑肌细胞(SMCs)是血管管壁的主要组成部分。SMCs表型与动脉粥样硬化斑块的稳定性密切相关,SMCs是构成斑块纤维帽的主要成分,较厚的纤维帽有利于增加斑块稳定性;相反,SMCs表型若转换为巨噬细胞样表型,可诱导纤维帽变薄,核心坏死增大,从而增加斑块不稳定性。SMCs表型转换机制与衰老、DNA损伤和凋亡有关。综述SMCs表型转化机制,通过调控SMCs表型以增加斑块稳定性,减少斑块破裂风险,降低不良心血管事件发生率。

Vascular smooth muscle cells(SMCs)were a major component of the vascular wall.SMCs phenotype was closely related to the stability of atherosclerotic plaque.SMCs were the main component of plaque fibrous cap, and thicker fibrous cap was beneficial to plaque stability.Conversely, phenotypic conversion of SMCs to a macrophage-like phenotype induce a thin fibrous cap and an enlarged necrotic core, thereby increasing plaque instability.Mechanism of phenotypic transition in SMCs was related to aging, DNA injury, and apoptosis.Regluation of the mechanisms of phenotypic transformation of SMCs could reduce the incidence of adverse cardiovascular events by modulating the phenotype of SMCs to increase plaque stability and reduce the risk of plaque rupture.