重复经颅磁刺激结合通络调神针法治疗抑郁症

Treatment of Depression with Repetitive Transcranial Magnetic Stimulation Combined with Tongluo Tiaoshen Acupuncture

目的:观察通络调神针法结合重复经颅磁刺激治疗抑郁症的临床疗效及安全性。方法:将72例抑郁症患者根据随机数字表法分为治疗组和对照组,每组36例。对照组给予口服草酸艾司西酞普兰,治疗组在对照组治疗基础上给予重复经颅磁刺激联合通络调神针法。比较两组患者治疗8周后临床疗效,两组患者治疗前、治疗2周、治疗4周、治疗6周、治疗8周的汉密尔顿抑郁量表(Hamilton′s depression scale, HAMD)评分、生存质量量表(SF-36)评分,治疗前后大脑前动脉(anterior cerebral arteries, ACA)、大脑中动脉(middle cerebral artery, MCA)、大脑后动脉(posterior cerebral artery, PCA)血流速度。结果:治疗组有效率为83.33%,显著高于对照组的69.44%,差异具有统计学意义(P<0.05)。两组患者治疗不同时间SF-36各维度评分均高于治疗前,差异均有统计学意义(P<0.05);治疗组治疗第2周、4周、6周、8周SF-36各维度评分均高于同期对照组,差异均有统计学意义(P<0.05)。两组患者治疗第2周、4周、6周、8周HAMD评分均低于本组治疗前,差异有统计学意义(P<0.05);治疗组HAMD评分均低于同期对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者ACA、MCA、PCA血流速度均高于本组治疗前,治疗组ACA、MCA、PCA血流速度高于同期对照组,差异均有统计学意义(P<0.05)。结论:通络调神针法结合重复经颅磁刺激治疗抑郁症疗效显著,可提高患者SF-36各维度评分,降低HAMD评分,提高患者ACA、MCA、PCA血流速度。

Objective: To observe the clinical efficacy and safety of repetitive transcranial magnetic stimulation combined with Tongluo Tiaoshen acupuncture in treatment of depression, and to guide the scientific treatment of depression.Methods: 72 patients with depression were randomly divided into treatment group and control group according to the method of random number table, with 36 patients in each group.The control group was given oral escitalopram oxalate, and the treatment group was given repeated transcranial magnetic stimulation combined with Tongluo Tiaoshen acupuncture on the basis of the treatment in the control group.Compare the clinical efficacy of the two groups of patients after 8 weeks of treatment.The Hamilton′s depression scale(HAMD) and quality of life scale(SF-36) scores of the two groups of patients before treatment, 2 weeks of treatment, 4 weeks of treatment, 6 weeks of treatment, and 8 weeks of treatment.The anterior cerebral artery(ACA),middle cerebral artery(MCA) Blood flow velocity of posterior cerebral artery(PCA).Results: The effective rate of patients in the treatment group was 83.33%,significantly higher than that in the control group(69.44%,P<0.05).The scores of SF-36 in each dimension of the two groups at different times of treatment were higher than those before treatment, and the difference was statistically significant(P<0.05).The scores of SF-36 in the treatment group were higher than those in the control group at the 2nd, 4th, 6th and 8th weeks of treatment(P<0.05).The HAMD scores of patients in the two groups at the 2nd, 4th, 6th and 8th week of treatment were lower than those before treatment(P<0.05).The HAMD score of the treatment group was lower than that of the control group at the same time, and the difference was statistically significant(P<0.05).After treatment, the blood flow velocity of ACA,MCA and PCA in the two groups was higher than that before treatment, and the blood flow velocity of ACA,MCA and PCA in the treatment group was higher than that in the control group at the same time, the difference was statistically significant(P<0.05).Conclusion: Tongluo Tiaoshen acupuncture combined with repetitive transcranial magnetic stimulation has a significant effect on depression.It can improve the SF-36 scores, reduce the HAMD scores and improve the blood flow velocity of ACA,MCA and PCA.