中国成年女性宫颈癌患病率Meta分析

Prevalence of Cervical Cancer in Adult Women in China:A Meta-Analysis

目的:系统评价2012年至今中国成年女性(≥18岁)宫颈癌患病率。方法:计算机检索PubMed、Embase、The Cochrane Library、Web of Science、中国知网(CNKI)、万方、维普及中国生物医学文献数据库(CBM),收集关于中国成年女性宫颈癌患病率的横断面研究,检索时限为2012年1月至2022年6月。由2名研究员独立筛选文献,提取资料,进行偏倚风险评价,采用Stata 17.0软件对纳入的研究进行Meta分析。结果:共纳入104个横断面研究,包括3305476例研究对象,1426例中国成年女性宫颈癌患者。Meta分析结果显示,近10年中国成年女性宫颈癌患病率为0.08%[95%CI(0.08%,0.09%)]。亚组分析结果:以经济带分组,东部经济带女性宫颈癌患病率为0.07%[95%CI(0.07%,0.08%)],中部经济带为0.08%[95%CI(0.07%,0.10%)],西部经济带为0.10%[95%CI(0.09%,0.11%)]。以居住地分组,城市女性宫颈癌患病率为0.08%[95%CI(0.08%,0.09%)],农村女性为0.08%[95%CI(0.07%,0.09%)]。以调查年份分组,2012~2016年度女性宫颈癌患病率为0.08%[95%CI(0.07%,0.08%)],2017~2022年度为0.10%[95%CI(0.09%,0.11%)]。结论:近10年我国成年女性(≥18岁)宫颈癌患病率呈上升趋势,我国宫颈癌患病率与经济发展呈负相关。

Objective:To systematically review the prevalence of cervical cancer among adult women(≥18 years old)in China since 2012.Methods:Databases including PubMed,Embase,the Cochrane Library,Web of Science,CNKI,WanFang Data,VIP Database and CBM were searched to collect cross-sectional studies on the prevalence of cervical cancer in Chinese adults from January 2012 to June 2022.Two reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies.Meta-analysis was then performed with Stata 17.0.Results:A total of 104 cross-sectional studies involving 3,305,476 subjects(1,426 cervical cancer patients)were included.The results of meta-analysis showed that the prevalence rate of cervical cancer in China was 0.08%[95%CI(0.08%,0.09%)]in recent 10 years.Subgroup analysis showed that the prevalence of cervical cancer was 0.07%[95%CI(0.07%,0.08%)]in more developed areas,0.08%[95%CI(0.07%,0.10%)]in less-developed regions,and 0.10%[95%CI(0.09%,0.11%)]in underdeveloped areas;the rate was 0.08%[95%CI(0.08%,0.09%)]in urban females,and 0.08%[95%CI(0.07%,0.09%)]in rural females;the rate was 0.08%[95%CI(0.07%,0.08%)from 2012 to 2016,and 0.10%[95%CI(0.09%,0.11%)]from 2017 to 2022.Conclusion:In recent 10 years,the prevalence of cervical cancer in Chinese women(≥18 years old)has been on the rise,and is negatively corelated to economic development.