清毒方联合化疗治疗术后毒壅气亏型直肠癌临床观察

Efficacy observation of Qingdu formula and chemotherapy on postoperative rectal cancer with syndrome of toxin stagnation and qi deficiency

目的:观察清毒方联合化疗治疗术后毒壅气亏型直肠癌的临床疗效。方法:选取符合纳入标准的直肠癌术后化疗患者60例,按照随机数字表法分为两组各30例,治疗组予清毒方联合奥沙利铂+卡培他滨化疗,对照组予奥沙利铂+卡培他滨化疗。比较两组血清CEA及CA199水平、中医证候积分、免疫功能、化疗毒副反应的变化。结果:治疗后,治疗组CEA、CA199水平及证候积分低于对照组(P<0.05);两组CD4+、CD4+/CD8+水平均较治疗前上升,CD8+水平较治疗前下降(P<0.05);且治疗组CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组(P<0.05)。治疗后,治疗组的骨髓抑制率(36.67%)低于对照组(73.33%),差异具有统计学意义(P<0.05)。结论:清毒方联合化疗治疗术后毒壅气亏型直肠癌效果良好,可改善患者临床症状及肿瘤标志物水平,提升免疫指标。

Objective:To observe the clinical efficacy of Qingdu formula and chemotherapy on postoperative rectal cancer with syndrome of toxin stagnation and qi deficiency.Methods:60 cases of selected patients with postoperative chemotherapy for rectal cancer,who met the inclusion criteria,were divided into two groups by method of random number table,30 cases in each group.The treatment group was treated with Qingdu formula and by chemotherapy of oxaliplatin and capecitabine,while the control group was treated by chemotherapy of oxaliplatin and capecitabine.The changes of serum CEA and CA199 levels,TCM symptom score,immune function and toxic and side effects of chemotherapy were compared between two groups.Results:After treatment,the levels of CEA and CA199 and the symptoms scores of treatment group were lower than those of control group(P<0.05).the levels of CD4+ and CD4+/CD8+ were increased in two groups compared with before treatment,while the level of CD8+ were decreased compared with before treatment(P < 0.05),and the levels of CD4+ and CD4+/CD8+ of treatment group were higher than those of control group,the level of CD8+ of treatment group was lower than that of control group(P<0.05).After treatment,the bone marrow inhibition rate of treatment group was 36.67%,which was lower than 73.33% of control group,and the difference was statistically significant(P < 0.05).Conclusion:The clinical efficacy of Qingdu formula and chemotherapy on postoperative rectal cancer with syndrome of toxin stagnation and qi deficiency is better,which can improve the clinical symptoms of patients and the level of tumor markers,and enhance the immune indexes.