银杏达莫注射液联合前列地尔注射液治疗急性脑梗死的临床疗效

Clinical effect of ginkgo dipyridamole injection combined with alprostadil injection for acute cerebral infarction

目的 观察银杏达莫注射液联合前列地尔注射液治疗急性脑梗死的临床疗效。方法 选取2020年10月—2021年10月湖南省中医药研究院附属医院接诊的急性脑梗死患者120例为研究对象,以电脑随机分配方式分为前列地尔组(n=60)和银杏达莫组(n=60)。前列地尔组患者予以前列地尔注射液治疗,银杏达莫组患者予以前列地尔注射液联合银杏达莫注射液治疗,2组均连续治疗2周。比较2组治疗前及治疗2周后血液流变学指标(血浆黏度、红细胞沉降率、D-二聚体)、炎性因子(白介素-6、超敏C反应蛋白、肿瘤坏死因子-α)、美国国立卫生研究院卒中量表(NIHSS)评分、生活质量评分,不良反应。结果 银杏达莫组患者治疗总有效率为98.33%,高于前列地尔组的86.67%(χ^(2)=4.324,P=0.038)。治疗2周后,2组患者血浆黏度、红细胞沉降率、D-二聚体、白介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平较治疗前降低,且银杏达莫组低于前列地尔组(P<0.01)。治疗2周后,2组患者NIHSS评分较治疗前降低、生活质量评分较治疗前升高,且银杏达莫组NIHSS评分低于前列地尔组,生活质量评分高于前列地尔组(P<0.01)。2组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 银杏达莫注射液联合前列地尔治疗急性脑梗死的临床疗效较好,可改善患者血液流变学指标,减轻炎性反应,恢复神经功能,提高生活质量,且安全性较高。

Objective To observe the clinical effect of ginkgo dipyridamole injection combined with alprostadil injection for acute cerebral infarction. Methods A total of 120 cases of patients with acute cerebral infarction were selected from October 2020 to October 2021 in Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, which were randomly divided into control group(n=60) and research group(n=60) by computer. Patients in the control group were treated with alprostadil injection, while patients in the research group were treated with alprostadil injection combined with ginkgo dipyridamole injection. Both groups were treated continuously for 2 weeks. Hemorheological indexes(plasma viscosity, erythrocyte sedimentation rate, D-dimer), inflammatory factors(interleukin-6, high-sensitivity C-reactive protein, tumor necrosis factor-α), National Institutes of Health Stroke Scale(NIHSS) score, quality of life score before and after 2 weeks of treatment, adverse reactions were compared between the two groups. Results The total effective rate of patients in the research group was 98.33%, was higher than 86.67% of the control group(χ^(2)=4.324, P=0.038). After 2 weeks of treatment, the plasma viscosity, erythrocyte sedimentation rate, D-dimer, interleukin-6, high-sensitivity C-reactive protein and tumor necrosis factor-α levels in the two groups were lower than those before treatment, and those in the research group were lower than control group(P<0.01). After 2 weeks of treatment, the NIHSS score of the two groups was lower than that before treatment, and the quality of life score was higher than that before treatment, the NIHSS score of the research group was lower than that of the control group, but the quality of life score of the research group was higher than that of the control group(P<0.01). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Ginkgo dipyridamole injection combined with alprostadil injection have an exact clinical effect for acute cerebral infarction, which can improve the hemorheological indexes of patients, reduce inflammatory reaction, restore nerve function and improve quality of life, and with high safety.