南疆库尔勒、喀什、阿克苏地区代谢综合征与胆囊息肉的相关性

The correlation between metabolic syndrome and gallbladder polyps in Korla, Kashgar and Aksu regions of southern Xinjiang

目的:探究南疆库尔勒、喀什、阿克苏地区三地代谢综合征(MS)与胆囊息肉(PLG)的相关性,为南疆地区PLG的预防及治疗提供依据,减少该地区此疾病的社会经济负担。方法:收集2014年3月1日~2019年3月1日在新疆南疆地区3家师级医院住院的PLG患者的资料,经过纳入排除标准筛选后得到193例PLG病例组资料。收集同期新疆南疆某医院体检人群的资料,通过年龄、性别1∶2匹配,得到386例对照组资料。整理资料后使用SPSS26.0软件进行数据分析,使用Logistic回归分析MS及其异常组分与PLG的相关性。结果:PLG组中MS患病率高于非PLG组,差异有统计学意义(P<0.05),PLG组仅高密度脂蛋白(HDL)与对照组差异有统计学意义(P<0.05);在单因素分析时,MS组分中只有血压增加PLG的患病风险(OR=1.60,95%CI:1.12~2.30);在多因素分析中,MS组分中血脂血压两组分增加了PLG的患病风险;其中血脂(OR=1.46,95%CI:1.01~2.12);血压(OR=1.55,95%CI:1.07~2.24);MS组PLG的患病风险是非MS组的1.86倍(OR=1.86,95%CI:1.16~2.98)。结论:随着HDL值降低、血压升高,新疆南疆地区PLG的患病率增加;MS是PLG的危险因素,在多因素分析时,MS其中两个组分血脂异常和高血压也是PLG的危险因素。

Objective To explore the correlation between Metabolic syndrome(MS) and polypoid lesion of gallbladder(PLG) in Korla, Kashgar and Aksu regions of southern Xinjiang, so as to provide evidence for the prevention and treatment of PLG in southern Xinjiang. To reduce the socio-economic burden of the disease in the region.Method The data of PLG patients hospitalized in 3 division-level hospitals in southern Xinjiang from March 1, 2014 to March 1, 2019 were collected. The data of 193 PLG case groups were obtained after inclusion and exclusion criteria screening. A total of 386 cases of control group were obtained by matching age and sex 1∶2. After sorting out the data, SPSS26.0 software was used for data analysis, and Logistic regression was used to analyze the correlation between MS and its abnormal components and PLG.Results The prevalence of MS in PLG group was higher than that in non-PLG group(P<0.05),the difference between PLG group and control group was statistically significant only in high-density lipoprotein(P<0.05).In univariate analysis, only blood pressure increased the risk of PLG among MS components(OR=1.60, 95%CI: 1.12~2.30);In multivariate analysis, two components of MS, blood lipid and blood pressure, increased the risk of PLG. Blood lipid(OR=1.46, 95%CI: 1.01~2.12);Blood pressure(OR=1.55, 95%CI: 1.07~2.24);The risk of PLG in MS group was 1.86 times higher than that in non-MS group(OR=1.86, 95%CI: 1.16~2.98).Conclusion With the decrease of HDL and the increase of blood pressure, the prevalence of PLG in southern Xinjiang increased;MS is a risk factor for PLG,in multivariate analysis, dyslipidemia and hypertension, two components of MS, were also risk factors for GS.