NLR、PLR、RDW和MPV在慢性阻塞性肺疾病急性加重期中的临床价值

Clinical value of NLR, PLR, RDW and MPV in acute exacerbation of chronic obstructive pulmonary disease

目的:探讨中性粒细胞和淋巴细胞比值(NLR)、血小板和淋巴细胞比值(PLR)、平均血小板体积(MPV)、红细胞分布宽度(RDW)在慢性阻塞性肺疾病急性加重期(AECOPD)病情及治疗中的临床价值。方法:选择110例慢性阻塞性肺疾病(COPD)患者,其中70例AECOPD患者作为急性加重组,40例COPD稳定期患者作为稳定组,同期100例健康体检者为对照组。检测各组的NLR、PLR、 RDW、 MPV和C-反应蛋白(CRP)的水平,对急性加重组治疗前后及稳定组、对照组两两之间进行比较;对急性加重组NLR、PLR、 RDW、 MPV和CRP的水平进行相关性分析。结果:急性加重组治疗前NLR、PLR、 RDW和CRP的水平显著高于稳定组和对照组,差异有统计学意义(P<0.05),MPV低于稳定组和对照组,差异有统计学意义(P<0.05);稳定组NLR、PLR、 RDW和CRP的水平高于对照组,差异有统计学意义(P<0.05),MPV低于对照组,差异有统计学意义(P<0.05);急性加重组治疗前NLR、PLR、 RDW和CRP的水平高于急性加重组治疗后,差异有统计学意义(P<0.05),MPV低于治疗后,差异有统计学意义(P<0.05)。AECOPD患者的NLR、PLR、 RDW与CRP呈正相关(r分别=0.73、0.57、0.36,P<0.05)MPV与CRP呈负相关(r=-0.42,P<0.05)。结论:NLR、PLR、 RDW、 MPV可用于评价AECOPD患者的病情情况以及治疗疗效,具有重要的临床应用价值。

Objective To explore the neutrophils and lymphocytes ratio(NLR), platelet and lymphocyte ratio(PLR), mean platelet volume(MPV), red blood cell distribution width(RDW) in chronic obstructive pulmonary diseases acute exacerbation(AECOPD) condition and treatment of clinical value. Method 110 cases of patients with chronic obstructive pulmonary disease(COPD) were selected, including 70 patients with AECOPD as acute and restructuring group, 40 patients with COPD stabilization as stable group, in the same period 100 cases of healthy check-up for a control group. The levels of NLR, PLR, RDW, MPV and CRP in each group were measured and compared before and after acute plus recombinant therapy and between the stable group and the control group;Correlation analysis was performed on the levels of acute plus recombinant NLR, PLR, RDW, MPV and CRP.Results The levels of NLR, PLR, RDW and CRP before acute and restructuring group were significantly higher than those in the stable group and the control group(P<0.05), MPV was lower than the stable group and the control group, the difference was statistically significant(P<0.05);The levels of NLR, PLR, RDW and CRP in the stable group were significantly higher than those in the control group(P<0.05), MPV was lower than the control group, the difference was statistically significant(P<0.05);The levels of NLR, PLR, RDW and CRP before treatment in acute and restructuring group were significantly higher than those after treatment in acute and restructuring group, the difference was statistically significant(P<0.05), MPV was lower than after treatment, the difference was statistically significant(P<0.05). Patients with AECOPD NLR, PLR, RDW and CRP were positively correlated(r=0.73, 0.57, 0.36, respectively, P<0.05), MPV and negatively correlated with CRP(r=-0.42, P<0.05). Conclusion NLR, PLR, RDW, MPV can be used for evaluating the effect of the illness and treatment in patients with AECOPD, has important clinical value.