摘要
再生障碍性贫血(AA)是一种骨髓造血衰竭性疾病,主要表现为骨髓造血功能低下、全血细胞减少和贫血/出血/感染征候群。异基因造血干细胞移植是治疗重型AA的重要手段。移植相关并发症的发生及管理仍是临床一巨大挑战,其预防和治疗可直接影响移植的效果、患儿长期的生存及生活质量。文章对AA患儿造血干细胞移植过程中常见移植并发症的诊断、预防及治疗进展予以阐述,以期提高患儿移植成功率及生存率。
Aplastic anemia(AA) is a bone marrow hematopoietic failure disorder that is characterized by low bone marrow hematopoiesis, complete blood cytopenia and anemia/hemorrhage/infection syndrome. Allogeneic hematopoietic stem cell transplantation is currently an important method in the treatment of severe AA. The occurrence and management of transplant-related complications remain a great clinical challenge, and their prevention and treatment can directly affect the outcome of transplantation, long-term survival and quality of life of the children. In this paper, we review the diagnosis,prevention and treatment of common transplant complications during HSCT in children with AA, with the aim of improving the success rate and survival rate of these transplanted children.
作者
徐佳伟
金润铭
XU Jiawei;JIN Runming(Department of Pediatrics,Union Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2023年第3期175-180,共6页
Journal of Clinical Pediatrics
关键词
再生障碍性贫血
异基因造血干细胞移植
并发症
儿童
aplastic anemia
allogeneic hematopoietic stem cell transplantation
complication
child