环境相关因素与先天性心脏病研究进展

Research progress on environmental factors and congenital heart disease

先天性心脏病是一种常见的出生缺陷,在我国发病率呈上升趋势,目前多认为先天性心脏病是遗传因素和环境因素共同作用的结果,但具体的发病机制尚不清楚。越来越多的研究聚焦于父母孕前及孕期环境暴露情况对先天性心脏病的影响,文章总结近年来与之相关的环境因素,概括潜在的影响机制,为防控先天性心脏病的发生提供参考。

Congenital heart disease(CHD)is a common birth defect,and its incidence is on the rise in China.At present,congenital heart disease is generally believed to be the result of the combined effect of genetic factors and environmental factors,but the specific etiology and pathogenesis are still not clear.More and more studies focus on the impact of parental environmental exposure before and during pregnancy on congenital heart disease.This article summarizes the environmental factors related to CHD in recent years,summarizes the potential influencing mechanism,and provides reference for preventing and controlling the occurrence of CHD.