PD-1抗体/PD-L1抗体在结直肠癌治疗中的应用现状及展望

Application of PD-1 pathway blockage in the treatment of colorectal cancer

结直肠癌是第二大最常见的肿瘤死亡原因。免疫治疗逐渐成为结直肠癌手术切除等常规治疗方式以外的另一种治疗方法。目前对抗PD-1/抗PD-L1药物疗效及不良反应的报道各不相同。本文将从PD-1信号通路及其阻断剂、PD-1/PD-L1抗体在结直肠癌中的临床应用、结直肠癌患者对免疫治疗的抵抗、PD-1/PD-L1抗体治疗的不良反应、预测PD-1/PD-L1抗体治疗疗效的生物学标志物等方面进行综述。

Colorectal cancer is the second common cause of cancer death.Immunotherapy has became a new therapy apart from traditional therapy such as surgery,etc.There are controversial about the efficiency and adverse reaction of anti-PD-1/PD-L1 drugs.In this article,the research and application of PD-1 pathway blockage are reviewed from the aspects of PD-1 pathway and blockage,clinical applications of anti-PD-1/PD-L1 drugs in colorectal cancer,treatment resistance,adverse reactions and biomarkers of effective prediction.